CHRNB4
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Official Full Name
cholinergic receptor, nicotinic, beta 4 -
Overview
Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene. -
Synonyms
neuronal acetylcholine receptor subunit beta-4;CHRNB4;OTTHUMP00000185021;neuronal nicotinic receptor beta 4 subunit;cholinergic receptor, nicotinic, beta polypeptide 4;cholinergic receptor, nicotinic, beta 4;ACHB4_HUMAN;Cholinergic receptor nicotinic beta 4;Cholinergic receptor nicotinic beta polypeptide 4;Nicotinic beta 4 Receptor
Recombinant Proteins
- Human
- Rat
- Chicken
- Mus musculus
- Bovine
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CHRNB4 involved in several pathways and played different roles in them. We selected most pathways CHRNB4 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | TAAR14E,RXFP2A,GRM8,TAAR10D,TAAR10B,APLNR,PTGER4A,SSTR4,HTR1E,NPBWR2 |
| Neuronal System | KCNS3A,KCNQ1,PANX1A,SNAP25A,KCNC1B,PANX1B,CHRNB2,SLC17A7A,SLC6A11,CCDC167 |
| Activation of Nicotinic Acetylcholine Receptors | CHRNE,CHRNA7,CHRNA3,CHRNA1,CHRND,CHRNA2,CHRNB2,CHRNA5,CHRNA4 |
| Acetylcholine Binding And Downstream Events | CHRND,CHRNA3,CHRNB2,CHRNA2,CHRNA4,CHRNA5,CHRNA1,CHRNE,CHRNA7 |
| Highly sodium permeable acetylcholine nicotinic receptors | CHRNB2,CHRNA4,CHRND,CHRNA3,CHRNE |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNB2,CHRNA1,CHRNA2,CHRNA4,CHRNA5,CHRNA3,CHRNA7 |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNA1,CHRNA4,CHRNA5,CHRNA3,CHRNB2,CHRNA2 |
| Cholinergic synapse | CHRNA6,GNAO1,PIK3CG,CREB3L1,GNAI3,KCNQ5,KCNJ3,KCNJ6,NRAS,GNB1 |
Protein Function
CHRNB4 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine receptor activity,acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB4 itself. We selected most functions CHRNB4 had, and list some proteins which have the same functions with CHRNB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-gated ion channel activity | CHRNB1,CHRNA4,TRPA1B,ZACN,GABRB1,ANXA6,CHRNA3,Chrng,CNGA3,P2RX2 |
| acetylcholine-activated cation-selective channel activity | CHRNB1L,CHRNA2,CHRNA5,CHRNA10A,CHRNB3,CHRNB2,CHRNA4B,CHRNA1,Chrng,CHRNB3A |
| drug binding | ATP5O,PPP3CA,ADH1,NAMPT,CHRNA3,P2RX2,CHRNA7,GRIK1,SFRP1,SIGMAR1 |
| protein heterodimerization activity | GCLC,SNX2,NEFH,MCL1,PDSS2,SMC1A,TWIST1,TAS1R2,HIST1H2AG,ITGA3 |
| acetylcholine receptor activity | CHRNB2,CHRNA3,CHRNA6,CHRNA5,CHRNA2,ANXA9,CHRNE,CHRNA4,CHRNA7 |
| contributes_to acetylcholine binding | CHRNA2A,CHRNA2,CHRNA4B,CHRNA10A,CHRNB3A,ZACN,CHRNA3,CHRNB1,CHRNB1L,CHRNA6 |
Interacting Protein
CHRNB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB4.
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References
- Gelernter, J; Kranzler, HR; et al. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. BIOLOGICAL PSYCHIATRY 77:493-503(2015).
- Sieminska, A; Jassem, E; et al. Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey. BMC PUBLIC HEALTH 15:-(2015).
