CHRNB2
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Official Full Name
cholinergic receptor, nicotinic, beta 2 (neuronal) -
Overview
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. -
Synonyms
Acetylcholine receptor beta 2 neural;ACHB2_HUMAN;ACHN;Acrb 2;Acrb2;b2 nAchR;Cholinergic receptor nicotinic beta 2;Cholinergic receptor nicotinic beta polypeptide 2;Cholinergic receptor nicotinic beta polypeptide 2 neuronal;CHRNB2;EFNL 3;EFNL3;nAChRB2;Neuronal acetylcholine receptor protein beta 2 chain precursor;Neuronal acetylcholine receptor protein subunit beta 2;Neuronal acetylcholine receptor subunit beta-2;Neuronal nicotinic acetylcholine receptor beta 2;cholinergic receptor, nicotinic, beta 2 (neuronal);cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal);Nicotinic beta 2 Receptor;OTTHUMP00000035374;Nicotinic beta 2 (carboxyl terminal) Receptor
Recombinant Proteins
- Human
- Rat
- Chicken
- Rhesus macaque
- Carassius auratus (Goldfish)
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&V5
- His&Fc&Avi
Involved Pathway
CHRNB2 involved in several pathways and played different roles in them. We selected most pathways CHRNB2 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Nicotinic Acetylcholine Receptors | CHRNA2,CHRNB4,CHRNE,CHRNA1,CHRNA5,CHRNA7,CHRNA4,CHRNA3,CHRND |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNA4,CHRNA7,CHRNA5,CHRNB4,CHRNA3,CHRNA2,CHRNA1 |
| Highly sodium permeable acetylcholine nicotinic receptors | CHRNA4,CHRND,CHRNE,CHRNA3,CHRNB4 |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNB4,CHRNA5,CHRNA3,CHRNA4,CHRNA1,CHRNA2 |
| Neuroactive ligand-receptor interaction | HTR7,TRPV1,HTR1B,NPY5R,GRIK3,HTR1F,SSTR2,NPBWR2,APLNRA,PRLHR2B |
| Acetylcholine Binding And Downstream Events | CHRNA2,CHRNE,CHRNA7,CHRNB4,CHRNA1,CHRNA4,CHRNA3,CHRND,CHRNA5 |
| Cholinergic synapse | KCNQ4,GNG13,AKT2,CHRNA4,GNG7,PIK3R2,GNG11,ITPR1,PIK3CG,GNB4 |
| Neuronal System | KCNC3A,KCND3,MYO6,KCNK7,SLC6A1A,SLC1A2A,KCNJ11,BCHE,KCNC1,KCNK1B |
Protein Function
CHRNB2 has several biochemical functions, for example, acetylcholine binding,acetylcholine receptor activity,acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB2 itself. We selected most functions CHRNB2 had, and list some proteins which have the same functions with CHRNB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligand-gated ion channel activity | CLCA5,GABRB1,ZACN,CHRNB1,TRPA1B,CHRNA4,TRPA1A,ANXA6,P2RX2,CLCA2 |
| acetylcholine receptor activity | CHRNA5,CHRNA7,CHRNB4,CHRNA3,CHRNA2,CHRNE,CHRNA6,ANXA9,CHRNA4 |
| drug binding | CHRNA3,PYGM,MT2A,CHRNA7,PYGL,TLR8,CHRNA2,CHRNB4,HTR2C,ATP5O |
| acetylcholine-activated cation-selective channel activity | CHRNA4,CHRND,CHRNA4B,CHRNB4,CHRNB1L,CHRNA6,CHRNA3,CHRNB3,CHRNA10A,CHRNA2 |
| protein heterodimerization activity | HIST1H2A9,MAFG,CHUK,BIK,TAF12,HMG20A,MAFA,KCNB1,PPP3CA,HIST1H2BL |
| acetylcholine binding | CHRNA4,CHRNB3,CHRM3,CHRFAM7A,CHRNB1,CHRNA3,CHRNA7,ACHE |
| protein binding | UQCC1,MRPL28,GNAQ,GPATCH4,SIGLEC6,MRPS16,HLA-DRB4,C16orf5,CDK10,TNPO2 |
Interacting Protein
CHRNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB2.
CHRNA5;CHRNA4;CHRNA3
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