CHRM4
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Official Full Name
cholinergic receptor, muscarinic 4 -
Overview
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. -
Synonyms
Cholinergic Receptor Muscarinic 4;Chrm 4;CHRM4;HM 4;HM4;M4;cholinergic receptor, muscarinic 4;M4R;Muscarinic M4 Receptor;OTTHUMP00000205575;muscarinic acetylcholine receptor M4
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Xenopus laevis
- Mus musculus
- Rat
- Wheat Germ
- Mammalian Cell
- HEK293
- Protein Conjugation
- In Vitro Cell Free System
- E.coli expression system
- Non
- His
- His&Flag
- His&Fc&Avi
Involved Pathway
CHRM4 involved in several pathways and played different roles in them. We selected most pathways CHRM4 participated on our site, such as Amine ligand-binding receptors,Calcium Regulation in the Cardiac Cell,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class A Rhodopsin-like | GPR50,GPR18,NMUR1,DRD4,ADORA1,GPR6,GPR171,ADORA3,GPR45,GPR75 |
| GPCR ligand binding | RLN3,FFAR3,SCT,GPR37B,DRD4,NTS,OPN1MW,RXFP2,PTGDR2,SSTR1 |
| Class A/1 (Rhodopsin-like receptors) | NMS,TAC3,HCRT,MLN,CXCL13,PROK2,ADRA2C,NPFF,DRD3,LPAR5A |
| GPCR downstream signaling | CHRM2,EDN3,CCR8,ADCYAP1R1,PLEKHG2,EDN1,QRFPR,PYY,UTS2,DGKA |
| Amine ligand-binding receptors | ADRA1D,CHRM3,HRH3,DRD1,ADRB1,ADRA2B,TAAR1,ADRA2A,CHRM5,ADRa1A |
| Cholinergic synapse | PIK3R2,GNG13,MAPK3,PIK3CD,MAP2K1,KCNJ6,KCNQ5,AKT2,KCNQ2,CHRNA7 |
| G alpha (i) signalling events | CCR1,CCL35.2,SSTR1,OPN1SW,FPR-RS6,GPR17,RGS6,DRD4,OXGR1,APPB |
| Calcium Regulation in the Cardiac Cell | RGS18,CX30.3,CX44.1,RGS10,GNB3B,ADRB1,ADRa1A,RGS5,KCNJ3,RGS5B |
Protein Function
CHRM4 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM4 itself. We selected most functions CHRM4 had, and list some proteins which have the same functions with CHRM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled acetylcholine receptor activity | CHRM3,CHRM5B,CHRM1,CHRM5,CHRM5A,CHRM2,CHRM2A |
| guanyl-nucleotide exchange factor activity | ARFGEF1,SH2D3A,FARP2,DOCK4,DENND5B,VAV2,DOCK4B,RIC8,RAPGEF6,DENND1C |
Interacting Protein
CHRM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM4.
Resources
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References
- Meixner, M; Atanasova, S; et al. Expression of Acetylcholine Receptors by Experimental Rat Renal Allografts. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Conforti, P; Monteys, AM; et al. In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice. GENE THERAPY 20:678-685(2013).
