CHN1
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Official Full Name
chimerin (chimaerin) 1 -
Overview
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duanes retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
CHN1;chimerin (chimaerin) 1;CHN, Duane retraction syndrome 2 , DURS2;N-chimaerin;ARHGAP2;Chimerin 1 (GTPase activating protein;rho;2);n chimerin;RhoGAP2;A-chimaerin;Alpha-chimerin;CHIN_HUMAN;CHN;N chimaerin;N-chimerin;NC;Rho GTPase-activating protein 2;a2-chimaerin;OTTHUMP00000205333;OTTHUMP00000205334;OTTHUMP00000205335;OTTHUMP00000205339;OTTHUMP00000205340;OTTHUMP00000205342;DURS2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- Insect Cells
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Fc
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHN1-11192H | Recombinant Human CHN1, GST-tagged | E.coli | Human | GST | N-term-350a.a. | |
| CHN1-3093H | Recombinant Human CHN1 protein, His-tagged | E.coli | Human | His | 145-207 aa | |
| CHN1-12244Z | Recombinant Zebrafish CHN1 | Mammalian Cell | Zebrafish | His |
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| CHN1-1256H | Recombinant Human CHN1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHN1-1378R | Recombinant Rat CHN1 Protein | Mammalian Cell | Rat | His |
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| CHN1-2163C | Recombinant Chicken CHN1 | Mammalian Cell | Chicken | His |
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| CHN1-240H | Recombinant Human CHN1, Gly&Pro tagged | Insect Cell | Human | Fc | 2-459 a.a. |
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| CHN1-241H | Recombinant Human CHN1, His-GST tagged | Insect Cell | Human | Fc | 2-459 a.a. |
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| CHN1-001HCL | Recombinant Human CHN1 cell lysate | Insect Cell | Human | Non |
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| CHN1-002HCL | Recombinant Human CHN1 cell lysate | Insect Cell | Human | Non |
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| CHN1-0255H | Recombinant Human CHN1 protein, His&GST-tagged | Insect Cells | Human | His&GST | 2-459 a.a. |
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| CHN1-1036R | Recombinant Rat CHN1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CHN1-1036R-B | Recombinant Rat CHN1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CHN1-2197H | Recombinant Human CHN1 protein | Insect Cells | Human | Non | Ala2-Phe459 |
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| CHN1-3211HF | Recombinant Full Length Human CHN1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 459 amino acids |
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| CHN1-3230H | Recombinant Human CHN1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CHN1-3758H | Recombinant Human CHN1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Chn1-383M | Recombinant Mouse Chn1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
CHN1 involved in several pathways and played different roles in them. We selected most pathways CHN1 participated on our site, such as Regulation of RAC1 activity,Rho GTPase cycle,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RAC1 activity | RAP1GDS1,ARHGAP1,ABR,ARHGAP17,PREX2,CHN2,ARHGAP9,EPS8,ARHGEF25,DOCK6 |
| Rho GTPase cycle | DCLRE1B,TAGAP,DEPDC1B,ARHGEF17,ARHGAP4A,ARHGAP9,ARHGAP32,ARAP1,ARHGAP22,ARHGAP17 |
| Signaling by Rho GTPases | ARHGEF16,ARHGAP17B,KTN1,MKL1B,DEPDC1B,CHN2,PLEKHG2,ARHGAP10,RHOT1A,FGD4A |
| Signal Transduction | KREMEN1,CCRL2,PRKCHB,ARHGAP12,USP2,ARAP1,RHOF,FGD4A,BOC,RDH14 |
Protein Function
CHN1 has several biochemical functions, for example, GTPase activator activity,SH3/SH2 adaptor activity,ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHN1 itself. We selected most functions CHN1 had, and list some proteins which have the same functions with CHN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | GNAQ,GDI1,RGS14,ARHGAP26,RGS19,RGS9B,RGS5A,RASAL3,NCKAP1L,TBC1D25 |
| ephrin receptor binding | EFNA1,SDCBP,EFNB3,ANKS1B,CDK5,EFNA5B,GRB2,EFNB2A,SRC,EFNA5 |
| SH3/SH2 adaptor activity | SH2B2,SHB,STAP1,SH2D3C,HSH2D,NCK1,SLA,SH2D1A,GRAP,RUSC1 |
| protein binding | NLGN3,IYD,FBLN1,TNNI3,CAMTA2,MAL,C7orf50,IGFBP7,C2orf28,C14orf135 |
| metal ion binding | LNX2A,SOBPB,ZNF207A,HBB-Y,ZFP583,ZNF131,ATP1A1A.1,DTD1,MBNL3,CHSY1 |
Interacting Protein
CHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHN1.
NCK2;HEMK1;CDK5R1;ERBB2;RPS3A;GTF3C1;MAPK8IP2
Resources
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References
- Iwata, R; Ohi, K; et al. RacGAP alpha 2-Chimaerin Function in Development Adjusts Cognitive Ability in Adulthood. CELL REPORTS 8:1257-1264(2014).
- Ferreiro, JF; Rouhigharabaei, L; et al. Integrative Genomic and Transcriptomic Analysis Identified Candidate Genes Implicated in the Pathogenesis of Hepatosplenic T-Cell Lymphoma. PLOS ONE 9:-(2014).
