CHIT1
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Official Full Name
chitinase 1 (chitotriosidase) -
Overview
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. -
Synonyms
CHIT1;chitinase 1 (chitotriosidase);chitotriosidase-1;CHI3;CHIT;CHIT1_HUMAN;Chitinase 1;Chitinase-1;Chitotriosidase;EC 3.2.1.14;FLJ00314;MGC125322;Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase;OTTHUMP00000039092;OTTHUMP00000217083;OTTHUMP00000217084;OTTHUMP00000217085;plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase;CHITD
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Human Cell
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CHIT1 involved in several pathways and played different roles in them. We selected most pathways CHIT1 participated on our site, such as Amino sugar and nucleotide sugar metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHIT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amino sugar and nucleotide sugar metabolism | TSTA3,GMPPAA,GFPT2,GNPNAT1,HK3,CHIA.3,GNPDA2,CYB5R3,CYB5RL,NPL |
Protein Function
CHIT1 has several biochemical functions, for example, chitin binding,chitinase activity,endochitinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHIT1 itself. We selected most functions CHIT1 had, and list some proteins which have the same functions with CHIT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chitin binding | OVGP1,CHI3L2,Chil3,CHIA.4,CTBS,CHIA.3,CHIA,CHID1,FIBCD1,CHIA.2 |
| chitinase activity | CHIA.2,CHIA,CHIA.1,CHIA.4,CHIA.3,OVGP1,CHID1,CTBS |
Interacting Protein
CHIT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHIT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHIT1.
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