CHAT
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Official Full Name
choline O-acetyltransferase -
Overview
Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. -
Synonyms
CHAT;choline O-acetyltransferase;CHOACTase;choline acetylase;choline acetyltransferase
Recombinant Proteins
- Human
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293T
- Wheat Germ
- HEK293
- His
- Myc&DDK
- GST
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHAT-172H | Recombinant Human CHAT protein, His-tagged | E.coli | Human | His | Asp517~Pro732 | |
| CHAT-2464H | Recombinant Human CHAT protein, His-tagged | E.coli | Human | His | 399-748 aa | |
| CHAT-174H | Recombinant Human CHAT | Mammalian Cell | Human | His |
|
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| CHAT-175HCL | Recombinant Human CHAT HEK293T cell lysate | HEK293T | Human | Myc&DDK |
|
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| CHAT-176H | Recombinant Human CHAT protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 630 a.a. |
|
| CHAT-177H | Recombinant Human CHAT protein, GST-tagged | Wheat Germ | Human | GST | 649 a.a. - 748 a.a. |
|
| Chat-1836R | Recombinant Rat Choline O-Acetyltransferase | E.coli | Rat | Non |
|
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| CHAT-6178C | Recombinant Chicken CHAT | Mammalian Cell | Chicken | His |
|
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| CHAT-1021H | Recombinant Human CHAT Protein (Met1-Pro630), N-His tagged | E.coli | Human | His | Met1-Pro630 |
|
| CHAT-1357H | Recombinant Human CHAT protein, His-tagged | E.coli | Human | His | 120-733aa |
|
| CHAT-1359H | Recombinant Human CHAT protein, His&Myc-tagged | E.coli | Human | His&Myc | 120-733aa |
|
| CHAT-2666H | Recombinant Human CHAT Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| CHAT-2666H-B | Recombinant Human CHAT Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
Involved Pathway
CHAT involved in several pathways and played different roles in them. We selected most pathways CHAT participated on our site, such as Acetylcholine Neurotransmitter Release Cycle,Acetylcholine Synthesis,Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid biosynthesis | CEPT1,CDIPT,BCHE,GPAT2,PLBD1,CPNE1,CEPT1A,MGLL,AGPAT2,CPNE7 |
| Metabolism | NUBP1,SLC6A7,CERS4A,GCHFR,Sult2a6,CSNK1G2,CPNE7,GGT6,NHLRC1,RHAG |
| Metabolism of lipids and lipoproteins | PPM1LB,GGTLC1,NFYBB,SLC25A1,SACM1LA,ARSK,CLPS,SLC25A20,Alb,CYP2AD3 |
| Cholinergic synapse | GNG10,CHRM3,CREB5,CHRNA6,CREB3L3,GNG8,ACHE,CAMK4,PLCB4,FOS |
| Biogenic Amine Synthesis | DDC,DBH,COMT |
| Glycerophospholipid metabolism | GPD1C,CDS2,DGKZ,AGPAT9,PLA2G4AA,GPAT2,AGPAT2,DGKAA,ETNK2,DGKD |
| Acetylcholine Neurotransmitter Release Cycle | RERG,SNAP25B,CCDC167,PPFIA4,UNC13B,CPLX1,RAB3AB,CPLX2L,BZRAP1,STXBP1A |
| Acetylcholine Synthesis | CHKA,PEMT |
Protein Function
CHAT has several biochemical functions, for example, choline O-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHAT itself. We selected most functions CHAT had, and list some proteins which have the same functions with CHAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| choline O-acetyltransferase activity | CHATA |
Interacting Protein
CHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CHAT.
Resources
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References
- Wang, L; Ennis, M; et al. Characteristics of GABAergic and cholinergic neurons in perinuclear zone of mouse supraoptic nucleus. JOURNAL OF NEUROPHYSIOLOGY 113:754-767(2015).
- Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
