CGA
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Official Full Name
glycoprotein hormones, alpha polypeptide -
Overview
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CGA;glycoprotein hormones, alpha polypeptide;HCG;LHA;FSHA;GPHa;TSHA;GPHA1;CG-ALPHA;glycoprotein hormones alpha chain;FSH-alpha;LSH-alpha;TSH-alpha;lutropin alpha chain;follitropin alpha chain;thyrotropin alpha chain;choriogonadotropin alph
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Chicken
- Mouse
- Dog
- Human Pregnancy Urine
- CHO
- Mammalian Cells
- Wheat Germ
- Human Cells
- HEK293
- Yeast
- E.coli
- In Vitro Cell Free System
- Urine
- Non
- His
- GST
- Strep II
- Fc
- GST&His
- His&Myc
- Avi&Fc&His
- mFc
Involved Pathway
CGA involved in several pathways and played different roles in them. We selected most pathways CGA participated on our site, such as Amine-derived hormones,Androgen biosynthesis,Autoimmune thyroid disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | OXGR1A.1,ADORA2A,CALCA,RGS18,TAAR1,CNR1,ADRA2B,NMBB,CHRM3,OR2AP1 |
| Autoimmune thyroid disease | IFN-a,OSTN,IL10,CTLA4 |
| Amine-derived hormones | TPH2,DBH,DIO2,DDC |
| FSH signaling pathway | CYP19A1,AREG |
| Androgen biosynthesis | CYP17A1,PPP1R2,POMCB |
| G alpha (s) signalling events | ADORA2A,NPS,CALCB,RLN2,GCGA,ADORA2B,VIP2,CRH,NPSR1,CRHR1 |
| GPCR ligand binding | RGR,CCR8,SST,PRLH,NMUR1,RLN3A,GAL,NPS,PTH2,GPR132B |
| Class A/1 (Rhodopsin-like receptors) | CHRM1,GPBAR1,DRD1,GPR4,MLN,PENKB,SSTR5,GPR39,NMS,KEL |
Protein Function
CGA has several biochemical functions, for example, hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CGA itself. We selected most functions CGA had, and list some proteins which have the same functions with CGA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IGSF1,KHDRBS1,E2F8,COX17,PVRL3,CCDC130,ZFHX3,E4F1,TACC3,NDUFB9 |
| hormone activity | CCK,TTR,INS1,AMH,CALCA,FAM132A,PRL8A8,SST1.1,IGF3,RETNLB |
Interacting Protein
CGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CGA here. Most of them are supplied by our site. Hope this information will be useful for your research of CGA.
FSHB;CGB;PTN;PTPN12
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References
- Ramirez, GA; Rodriguez, F; et al. Morphologic and immunohistochemical features of Merkel cells in the dog. RESEARCH IN VETERINARY SCIENCE 97:475-480(2014).
- Glinicki, P; Jeske, W; et al. Comparison of chromogranin A (CgA) levels in serum and plasma (EDTA(2)K) and the respective reference ranges in healthy males. ENDOKRYNOLOGIA POLSKA 66:53-56(2015).
