CFLAR

  • Official Full Name

    CASP8 and FADD-like apoptosis regulator

  • Overview

    The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

  • Synonyms

    CFLAR;CASP8 and FADD-like apoptosis regulator;CASH;FLIP;MRIT;CLARP;FLAME;Casper;FLAME1;c-FLIP;FLAME-1;I-FLICE;c-FLIPL;c-FLIPR;c-FLIPS;CASP8AP1;usurpin beta;caspase homolog;inhibitor of FLICE;caspase-eight-related protein;MACH-related inducer of toxicity;FADD-like anti-apoptotic molecule;FADD-like antiapoptotic molecule 1;caspase-related inducer of apoptosis;cellular FLICE-like inhibitory protein;caspase-like apoptosis regulatory protein

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Rat
  • Human
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • Non
  • GST
  • His
  • His&T7
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
CFLAR-3638H Recombinant Human CFLAR Human Human Non 1-480 a.a.
CFLAR-1176H Recombinant Human CFLAR Protein, GST-Tagged Wheat Germ Human GST
CFLAR-28415TH Recombinant Human CFLAR E.coli Human Non 480 amino acids
CFLAR-4496C Recombinant Chicken CFLAR Mammalian Cell Chicken His
CFLAR-7553HCL Recombinant Human CFLAR 293 Cell Lysate HEK293 Human Non
Cflar-1831M Recombinant Mouse Cflar protein, His & T7-tagged E.coli Mouse His&T7 Asn210~Gly460
Cflar-1832R Recombinant Rat Cflar protein, His & T7-tagged E.coli Rat His&T7 Arg43~Tyr281
CFLAR-2722H Recombinant Human CFLAR Protein (Asp31-Asn184), N-His tagged E.coli Human His Asp31-Asn184
CFLAR-3298HF Recombinant Full Length Human CFLAR Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 480 amino acids
Cflar-882M Recombinant Mouse Cflar Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    CFLAR involved in several pathways and played different roles in them. We selected most pathways CFLAR participated on our site, such as NF-kappa B signaling pathway,Apoptosis,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFLAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis IRAK1,DIABLOB,NFKBIA,DCC,CTNNB2,CAPN2B,TNFRSFA,NTRK1,CASP10,Gzmg
    Chagas disease (American trypanosomiasis) MAPK3,PLCB1,PPP2R2D,TLR9,PIK3CD,ACE,TNFRSF1A,CALR,TGFBR2,CXCL8
    TNF signaling pathway PIK3R1,PGAM5,CREB3L1,RPS6KA5,MAP2K6,Casp3,CASP8,PIK3CG,ICAM1,MAPK13
    NF-kappa B signaling pathway MAP3K7IP3,TNFSF11,NFKBIA,TRAF1,GM13304,LTA,LY96,PLCG1,CD40LG,RELB

    Protein Function

    CFLAR has several biochemical functions, for example, cysteine-type endopeptidase activity involved in apoptotic signaling pathway,death effector domain binding,death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFLAR itself. We selected most functions CFLAR had, and list some proteins which have the same functions with CFLAR. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RBM5,USP44,ZBTB24,PIP,MIS12,HIP1R,AIDA,PENK,ARF5,BCCIP
    protease binding CNTNAP2,CCDC71L,BRCA2,COMP,TIMP2B,SERPINE1,SERPINB3,ANXA2,TYSND1,CST3
    protein complex binding ING2,DRD1A,KHDRBS1,PGAM5,CAPG,MTAP1B,NRAS,IGBP1,PTPRF,TRAF2
    death receptor binding TNFSF15,PIDD1,FASLG,BID,MYD88,Casp3,FADD,Fasl,RIPK1,NOL3
    death effector domain binding CASP10,NOL3,CASP8L1,CFLARA,CASP8,FADD
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway CASP8,CASP14,CASP2,CASP9,CASP10,CFLARA,CASP8L1
    enzyme activator activity TRIM23,PSAP,PITRM1,CXCL1,GTF3C4,ALDH1A2,SLX4,MMP16,DNMT3L,DCP1B

    Interacting Protein

    CFLAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFLAR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFLAR.

    CASP10;CASP8;TRAF1;TNFSF10;b4dyc6_human;EIF3F;DOK2

    Resources

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