CES5A
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Official Full Name
carboxylesterase 5A -
Overview
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CES5A;carboxylesterase 5A;carboxylesterase 7 , CES7;CAUXIN;CES4C1;CES5;FLJ31547;Carboxylesterase 5;Carboxylesterase 7;Carboxylesterase like urinary excreted protein;Carboxylesterase like urinary excreted protein homolog;CES 7;EC 3.1.1.1;carboxylesterase-like urinary excreted protein homolog;CES7
Recombinant Proteins
- Rat
- Human
- Rhesus macaque
- Mouse
- Mammalian Cell
- Wheat Germ
- Human Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&GST
Involved Pathway
CES5A involved in several pathways and played different roles in them. We selected most pathways CES5A participated on our site, such as E2F transcription factor network,Phase I, non P450,retinol biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| retinol biosynthesis | DHRS9,DHRS4,RBP5 |
| E2F transcription factor network | YY1,UXT,RBBP8,DHFR,CBX5,TRIM28,SMARCA2,E2F4,CES3,E2F6 |
Protein Function
CES5A has several biochemical functions, for example, sterol esterase activity,triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES5A itself. We selected most functions CES5A had, and list some proteins which have the same functions with CES5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| triglyceride lipase activity | LIPF,PNPLA3,CEL.1,LIPE,LPL,PNLIPRP3,LIPCA,PNLIP,PNLIPRP2,Cel |
| sterol esterase activity | Cel,CES1,CEL.1,LIPA,CES1D,CES3 |
Interacting Protein
CES5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES5A here. Most of them are supplied by our site. Hope this information will be useful for your research of CES5A.
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