CENPT
-
Official Full Name
centromere protein T -
Overview
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which;the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the;presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an;additional factor required for centromere assembly (Foltz et al., 2006 (PubMed 16622419)). -
Synonyms
CENPT;centromere protein T;C16orf56, chromosome 16 open reading frame 56;CENP T;FLJ13111;C16orf56;CENP-T;CENPT_HUMAN;Chromosome 16 open reading frame 56;ICEN22;Interphase centromere complex protein 22
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Chicken
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CENPT involved in several pathways and played different roles in them. We selected most pathways CENPT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CENPT has several biochemical functions, for example, endonuclease activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPT itself. We selected most functions CENPT had, and list some proteins which have the same functions with CENPT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endonuclease activity | ANG3,ZC3H12A,APEX1,RAG1,PELO,G3BP1,EAR14,EAR5,NTHL1,ENDOU2 |
| metal ion binding | MICALL2A,PRLR,ZNF35,HARBI1,TRAF4A,ESRRGA,DMRT1,ALKBH5,NRP2,NR4A2A |
| protein binding | DDB1,TRIP10,FBXL15,EYA2,P4HB,FGFRL1A,CYTIP,ZNF649,CCDC28A,TXN2 |
Interacting Protein
CENPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPT here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPT.
CENPW;APITD1;TCEA2;SNCB;DHX29;PPCDC;ITGB3BP;CENPU;CENPQ;CENPO;Cenph
Resources
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References
- Song, G; Hu, CJ; et al. New Centromere Autoantigens Identified in Systemic Sclerosis Using Centromere Protein Microarrays. JOURNAL OF RHEUMATOLOGY 40:461-468(2013).
- Saito, A; Muro, Y; et al. Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:57-63(2013).
