CENPE

  • Official Full Name

    centromere protein E, 312kDa
  • Overview

    Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq, Jul 2008]
  • Synonyms

    CENPE;centromere protein E, 312kDa;KIF10;CENP-E;PPP1R61;centromere-associated protein E;kinesin family member 10;kinesin-related protein CENPE;Centromere autoantigen E (312kD);protein phosphatase 1, regulatory subunit 61
Cat.# Product name Source (Host) Species Tag Protein Length Price
CENPE-3800H Recombinant Human CENPE protein, His-tagged E.coli Human His 2401-2500 aa
CENPE-1114H Recombinant Human CENPE Protein, GST-Tagged Wheat Germ Human GST
CENPE-348H Recombinant Human CENPE Protein, His-tagged E.coli Human His Ala2450~Arg2590
Cenpe-349R Recombinant Rat Cenpe Protein, His-tagged E.coli Rat His Ala2222~Arg2361
CENPE-4563Z Recombinant Zebrafish CENPE Mammalian Cell Zebrafish His

    Involved Pathway

    CENPE involved in several pathways and played different roles in them. We selected most pathways CENPE participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle CSNK1D,CCNB2,GADD45B,MYC,CCND2,NDC80,INCENP,SFN,CSNK2A1,CDC25C
    Mitotic Anaphase CENPC1,CLIP1,SKA1,SPC24,ITGB3BP,NDEL1,CENPL,SGOL2,LEMD3,CENPI
    Kinesins KIF26A,KIF3B,KLC3,KIF22,RACGAP1,KIF15,KIF3C,KIF11,KIF9,KIF5A
    Cell Cycle, Mitotic LIN52,GOLGA2,GORASP2,RBBP4,AHCTF1,LIN9,KIF2B,CEP70,MAU2,CDK7
    Mitotic Metaphase and Anaphase CENPO,LEMD3,SKA2,SPC25,RCC2,NDEL1A,CENPH,MIS12,B9D2,PMF1
    Hemostasis ANXA2A,BA1L,CAP1,PDPN,SLC3A2B,BA2,AKAP1,KIF20A,STXBP3,HBBE1.1
    Factors involved in megakaryocyte development and platelet production OSTN,IRF2A,HBD,IRF1B,LRRC16A,KIF4A,KIF20A,MAFGA,DOCK1,DOCK9
    M Phase CENPC1,VRK2,NDC80,CDCA5,WAPAL,BLZF1,SPC25,CENPP,MCPH1,ENSA

    Protein Function

    CENPE has several biochemical functions, for example, ATP binding,ATPase activity,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPE itself. We selected most functions CENPE had, and list some proteins which have the same functions with CENPE. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding CAMSAP1,FNTA,KIF9,KIF22,DPYSL2,GOLSYN,REEP1,GABARAPL2,NUSAP1,PRC1A
    ATP binding KIF5C,GSK3B,SNRKB,WARS2,ACTBL2,DNAH14,PLK3,PRKCD,JAK2A,CAMKK1B
    ATPase activity MYH8,ABCB4,TOR1B,PSMC1,ABCC8,ABCA6,ATAD1A,KIF4,KIF14,EIF4A1A
    nucleotide binding UBE2D1B,RPS24,GNAI2A,NLRP4B,ATAD1A,HNRNPM,ABCA5,HPRT1,RBM10,TUBA7L
    microtubule motor activity KLC1B,KIF5C,DNAH14,DYNLRB2,BBS4,KIF27,DYNC2H1,KIF4A,KIF1B,KIF11

    Interacting Protein

    CENPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPE here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPE.

    Resources

    References

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