CDKN2D
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Official Full Name
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -
Overview
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) is a specific inhibitor of cyclin-dependent kinases CDK4 and CDK6. CDK4 is a subunit of the protein kinase complex that is important for cell cycle G1 phase progression. -
Synonyms
CDKN2D;cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4);cyclin-dependent kinase 4 inhibitor D;INK4D;p19;CDK inhibitor p19INK4d;inhibitor of cyclin-dependent kinase 4d;cyclin-dependent kinase 4 inhibitor D p19;cell cycle inhibitor, Nur77 a
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His&T7
- Non
- His
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
CDKN2D involved in several pathways and played different roles in them. We selected most pathways CDKN2D participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cyclin D associated events in G1 | CDK7,PIANP,CKS1B,E2F4,CDKN2B,CDKN2C |
| Cellular Senescence | ERF,PHC2,CDKN2C,SUZ12B,EED,LMNB1,PHC3,H3F3D,CBX6,KAT5 |
| FoxO signaling pathway | MAPK9,PLK4,GABARAPL1,HOMER1,PRKAB1A,PIK3R3,G6PC3,TGFB1A,PRKAG3B,SMAD2 |
| G1 Phase | PIANP,CDKN2B,CKS1B,CDKN2C,E2F4 |
| Cell Cycle, Mitotic | CENPE,HIST4H4,CLASP1A,MYBL2,VRK1,TUBG2,PIANP,E2F3,CEP63,NINL |
| Cell cycle | PTTG2,CENPL,CCNE2,MYCA,RAD21A,CUL1,FAM175A,BABAM1,DKC1,YWHAE2 |
| Cellular responses to stress | TXN,H3F3D,EHMT2,CDKN2C,HIF1AL,ATG9A,TXNRD2,UVRAG,CBX8A,EP400 |
Protein Function
CDKN2D has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2D itself. We selected most functions CDKN2D had, and list some proteins which have the same functions with CDKN2D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLD3,NT5C2,GRAMD3,FOXK2,SQSTM1,CASC3,CREB3L1,PAK4,NAA10,STON2 |
| protein kinase binding | MAML1,ADAM10,CCNK,PRC1,BAG5,RFFL,PTPN2,HCLS1,KCNQ3,HDAC7A |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN2A,CDKN1A,INCA1,CDKN2B,HEXIM2,CDKN1BA,CDKN1D,HEXIM1,CDKN1C,Casp3 |
Interacting Protein
CDKN2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2D here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2D.
CDK6;CDK4;C1orf94;IKZF3;NR4A2
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References
- Kannan, K; Coarfa, C; et al. CDKN2D-WDFY2 Is a Cancer-Specific Fusion Gene Recurrent in High-Grade Serous Ovarian Carcinoma. PLOS GENETICS 10:-(2014).
- Wang, Y; Jin, W; et al. Transcriptional repression of CDKN2D by PML/RAR alpha contributes to the altered proliferation and differentiation block of acute promyelocytic leukemia cells. CELL DEATH & DISEASE 5:-(2014).
