CDKN1C
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Official Full Name
cyclin-dependent kinase inhibitor 1C (p57, Kip2) -
Overview
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
CDKN1C;cyclin-dependent kinase inhibitor 1C (p57, Kip2);BWS;WBS;p57;BWCR;KIP2;cyclin-dependent kinase inhibitor 1C;p57Kip2;cyclin-dependent kinase inhibitor p57;P57;OTTHUMP- 00000011736;OTTHUMP00000011738;Beckwith- Wiedemann syndrome;OTTHUMP00000229152
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDKN1C-11061H | Recombinant Human CDKN1C, His-tagged | E.coli | Human | His | 1-316a.a. | |
| CDKN1C-1059H | Recombinant Human CDKN1C Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDKN1C-275Z | Recombinant Zebrafish CDKN1C | Mammalian Cells | Zebrafish | His |
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| CDKN1C-30575TH | Recombinant Human CDKN1C | Wheat Germ | Human | Non | 100 amino acids |
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| CDKN1C-3222M | Recombinant Mouse CDKN1C Protein | Mammalian Cells | Mouse | His |
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| CDKN1C-1536M | Recombinant Mouse CDKN1C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDKN1C-1536M-B | Recombinant Mouse CDKN1C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CDKN1C involved in several pathways and played different roles in them. We selected most pathways CDKN1C participated on our site, such as Cell cycle,Endochondral Ossification,G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | TMPO,GINS4,NIPBLA,CLSPN,E2F4,BARD1,EP300,CDKN2C,NCAPG,SKA1 |
| G1 to S cell cycle control | MYT1,ATF6B,E2F6,TFDP1B |
| Endochondral Ossification | DDR2,CTSL2,COL2A1,ADAMTS1,RUNX3,SOX9A,NKX3-2,MMP13,FRZB,KIF3A |
Protein Function
CDKN1C has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1C itself. We selected most functions CDKN1C had, and list some proteins which have the same functions with CDKN1C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase inhibitor activity | INCA1,CDKN2A,KAT2B,HEXIM1,CDKN2B,HEXIM2,CDKN1D,CDKN1BA,CDKN1A,Casp3 |
| protein binding | MAL,FXR2,TRAPPC5,RPL22,JMJD6,NFKBIZ,LRFN4,TYK2,SLN,MGAT5B |
Interacting Protein
CDKN1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1C.
CDK2;MCM7;FBXL12;Cdk1;CDK4;PCNA;CCNE2
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