CDK11A
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Official Full Name
cyclin-dependent kinase 11A -
Overview
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. -
Synonyms
CDK11A;cyclin-dependent kinase 11A;CDC2L2, CDC2L3, cell division cycle 2 like 2 , cell division cycle 2 like 2 (PITSLRE proteins);CDK11 p46;CDK11 p58;CDK11 p110;p58GTA;PITSLRE;CD11A_HUMAN;CDC2L2;CDC2L3;CDK11;CDK8 like cyclin dependent kinase;Cell division cycle 2 like protein kinase 2;Cell division cycle 2-like protein kinase 2;Cell division protein kinase 11A;Cyclin dependent kinase (CDC2 like) 11;Death preventing kinase;Galactosyltransferase associated protein kinase p58/GTA;Galactosyltransferase-associated protein kinase p58/GTA;PITSLRE protein kinase beta;PITSLRE serine/threonine-protein kinase CDC2L2;PITSLREB;serine/threonine-protein kinase CDC2L2;PITSLRE B;OTTHUMP00000000760;OTTHUMP00000000762;OTTHUMP00000000763;OTTHUMP00000000764;OTTHUMP00000000767;OTTHUMP00000000768;cell division cycle 2-like 2 (PITSLRE proteins);CDK11-p46;CDK11-p58;CDK11-p110
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK11A-0922H | Recombinant Human CDK11A Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDK11A-26652TH | Recombinant Human CDK11A, His-tagged | E.coli | Human | His | 350-636 a.a. |
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| CDK11A-285H | Recombinant Human CDK11A protein, GST-tagged | Insect Cells | Human | GST | 361-end a.a. |
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| CDK11A-722H | Recombinant Human CDK11A Protein, His-tagged | E.coli | Human | His | Glu422-Ile646 |
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Involved Pathway
CDK11A involved in several pathways and played different roles in them. We selected most pathways CDK11A participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Centrosome maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Recruitment of mitotic centrosome proteins and complexes | NUMA1,TUBGCP5,TUBGCP2,CDK11B,TUBGCP3,TUBG2,TUBGCP4 |
| Cell Cycle, Mitotic | FOXM1,ESCO2,WAPAL,STAG1,SDCCAG8,HAUS2,PIANP,KIF18A,CEP78,CDKN2C |
| Cell cycle | TUBGCP2,HUS1,CENPK,ARF1,YWHAE1,CEP152,PANE1,CDK5RAP2,NDEL1B,SMAD3A |
| G2/M Transition | DYNC1I2,LIN9,CEP135,TUBG2,TUBGCP5,CLASP1A,LIN52,CEP72,ACTR1A,DCTN2 |
| Centrosome maturation | TUBG1,NUMA1,CDK11B,MAPRE1A,CLASP1A,TSGA14,DCTN1,NINL,CKAP5,DYNC1H1 |
| Mitotic G2-G2/M phases | TUBGCP2,LIN37,LIN9,BORA,TUBG2,LIN52,TUBGCP5,TCTN2,TUBGCP3,FOXM1 |
Protein Function
CDK11A has several biochemical functions, for example, ATP binding,cyclin-dependent protein serine/threonine kinase activity,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK11A itself. We selected most functions CDK11A had, and list some proteins which have the same functions with CDK11A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase activity | NAT1,CDKL3,CDK7,CDKL4,CDK6,CDK19,MOK,CDK8,CDK12,MAK |
| ATP binding | CDC34B,UBA6,ABCC3,QRSL1,DHX32A,MYO18A,PSMC1B,CDC6,QARS,ITPKC |
| protein serine/threonine kinase activity | CDK15,DAPK2,PSKH1,AURKA,MASTL,SNRKB,SRPK1B,CSNK1E,STK33,MAP4K4 |
| protein kinase activity | SIK2A,JAK2A,PRKCHB,IRAK4,PAK2,PIK3CG,PAK2A,BMPR1BB,EPHA4A,POMK |
Interacting Protein
CDK11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK11A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK11A.
CSNK2A2;CSNK2A1;CDC37;Dlg4;HSP90AB1;GADD45A;SKIV2L;pi3p;PRPF40A;A2M;HSP90AA1;HKR1;RBM25;KPNA2;CSNK2B;ZNF33A
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References
- Kamal, A; Reddy, VS; et al. Synthesis of imidazo[2,1-b][1,3,4]thiadiazole-chalcones as apoptosis inducing anticancer agents. MEDCHEMCOMM 5:1718-1723(2014).
- Wang, JH; Wang, QD; et al. Design, Synthesis and Preliminary Biological Evaluation of Purine-2,6-diamine Derivatives as Cyclin-dependent Kinase (CDK) Inhibitors. CHINESE JOURNAL OF CHEMISTRY 31:1181-1191(2013).
