CDK1
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Official Full Name
cyclin-dependent kinase 1 -
Overview
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CDC2;CDC28A;P34CDC2;MGC111195;DKFZp686L20222;cyclin-dependent kinase 1;OTTHUMP00000019659;OTTHUMP00000019660;OTTHUMP00000223862;p34 protein kinase;cell cycle controller CDC2;cell division protein kinase 1;cell division control protein 2 homolog;cell division cycle 2, G1 to S and G2 to M;cdk1-a;cyclin-dependent kinase 1-A;Cdc 2;CDK 1;CDK1;CDK1_HUMAN;Cell division control protein 2;Cell division cycle 2 G1 to S and G2 to M;Cell Divsion Cycle 2 Protein;Cyclin Dependent Kinase 1;p34 Cdk1;p34 protein kinase 1;cell division cycle 2 like;cell division protein kinase 1-A;cell division control protein 2-A;Cell division control protein 2 homolog 1;cdc-2;xcdc2;cdc2-a
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Chicken
- Rhesus macaque
- Insect Cells
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- Fc
- GST
- His
- His&T7
- GST&His
- Non
- DDK&Myc
- Flag
- Avi&Fc&His
Involved Pathway
CDK1 involved in several pathways and played different roles in them. We selected most pathways CDK1 participated on our site, such as Cell cycle,Oocyte meiosis,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | TNFRSF10B,APAF1,GTSE1,FAS,BID,SIAH2L,PMAIP1,THBS1,Casp3,RCHY1 |
| Viral carcinogenesis | GTF2E1,PIK3R5,HIST1H2BM,NFKB1,YWHAZ,PXN,PRKACG,GTF2A2,HIST1H4K,PMAIP1 |
| Cell cycle | NDC80,KIF20A,YWHABB,FKBP6,CENPK,CCNB1,FOXM1,ANAPC4,GADD45BA,ORC3 |
| Herpes simplex infection | NFKBIAB,SRSF5B,HLA-B,PVRL1B,TAP1,CASP3A,MYD88,NXF2,SRPK1B,BLB2 |
| Oocyte meiosis | IGF1R,CALML3,YWHAG1,ITPR1,PPP3CB,PPP3CA,PPP2R1B,MAPK1,YWHAE2,CDC20 |
| Epstein-Barr virus infection | TRAF3,RELA,FGR,CD38,HLA-E,MAPK10,NFKB2,HLA-DRB5,POLR3K,PSMC1 |
| Gap junction | TUBA8,GNA15.4,HRAS,PLCB4,GNA11A,TUBA4L,TUBA8L3,TUBB5,RAF1B,PLCB2 |
| Progesterone-mediated oocyte maturation | PRKACG,CCNA2,RPS6KA1,ADCY1B,PIK3R3B,MAD2L1,MAPK9,AKT2,PIK3R3A,PRKACBB |
Protein Function
CDK1 has several biochemical functions, for example, ATP binding,Hsp70 protein binding,RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK1 itself. We selected most functions CDK1 had, and list some proteins which have the same functions with CDK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | HIPK3,RIOK3,NEK5,SMOK2B,PASK,SMOK3B,MARK4,TAOK2,IRAK3,MELK |
| Hsp70 protein binding | RNF207,TSACC,L7RN6,PPID,C11orf73,FAM119A,DNAJB2,PACRG,GPR37,DNAJC10 |
| protein binding | CEP63,IL5RA,WDR6,GHR,TRIM39,SLX1B,VANGL1,MAFB,SR140,NECAB3 |
| ATP binding | FLAD1,ABCC3,TDRD12,ANKK1,KIF2A,DDR1,PLK2B,PAK2,TGFBR2,SMARCA5 |
| RNA polymerase II carboxy-terminal domain kinase activity | CDK13,MAPK1,CDK12,CDK7,CDK9,CCNK,CDK8 |
| protein kinase activity | PTK2AB,GRK1,ROCK2A,KALRN,MAP4K6,ZNF143B,IRAK1,CAMK2G1,SRPK1B,SGK196 |
| histone kinase activity | CCNB1,BAZ1B |
| cyclin-dependent protein serine/threonine kinase activity | CDK5,CDK2,CDKL3,ICK,CDK10,CDK15,CDK17,MAK,CDK20,CCNK |
Interacting Protein
CDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK1.
CCNB1;CKS1B;PKMYT1
CDK1 Related Signal Pathway
Resources
Research Area
Intracellular Kinases in the Akt PathwayCyclin-Dependent Protein Kinases (CDKs)
G2/M (DNA Damage) Checkpoints
CDKs (Cyclin Dependent Kinases)
Related Services
Related Products
References
- Zhu, BT; Xiahou, ZK; et al. MTHFR promotes heterochromatin maintenance. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 447:702-706(2014).
- Matthess, Y; Raab, M; et al. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. MOLECULAR ONCOLOGY 8:596-608(2014).
