CDH18
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Official Full Name
cadherin 18, type 2 -
Overview
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. -
Synonyms
CDH18;cadherin 18, type 2;cadherin-18;CDH14;EY CADHERIN;cadherin-14;ey-cadherin;cadherin-like 24;CDH24;CDH14L
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- E.coli
- Wheat Germ
- Human Cell
- HEK293
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDH18-11034H | Recombinant Human CDH18, GST-tagged | E.coli | Human | GST | 25-382a.a. | |
| CDH18-0979H | Recombinant Human CDH18 Protein, GST-Tagged | Wheat Germ | Human | GST |
|
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| CDH18-47H | Recombinant Human CDH18 protein, T7/His-tagged | E.coli | Human | His&T7 | 54-608 a.a. |
|
| CDH18-85C | Recombinant Cynomolgus CDH18, His tagged | Human Cell | Cynomolgus | His | 1-608 a.a. |
|
| CDH18-765CCL | Recombinant Cynomolgus CDH18 cell lysate | Human Cell | Cynomolgus | Non |
|
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| CDH18-097R | Recombinant Rhesus CDH18 protein, His-tagged | HEK293 | Rhesus macaque | His | Met1-Ser608 |
|
| CDH18-3139HF | Recombinant Full Length Human CDH18 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 790 amino acids |
|
| CDH18-718H | Recombinant Human CDH18 Protein, His-tagged | E.coli | Human | His | Gly54-Phe268 |
|
Involved Pathway
CDH18 involved in several pathways and played different roles in them. We selected most pathways CDH18 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-Cell communication | PLEC,CD151,SIRPB1,CDH17,PARVB,CDH9,FBLIM1,PVRL2L,CDH7,CLDN7 |
| Cell-cell junction organization | CDH12,CDH13,CDH12A,CLDN16,CADM2,PVRL1A,CTNND1,CDH5,INADL,CADM2B |
| Cell junction organization | PVRL2L,CADM2,CDH5,CDH7,CLDN23,CDH6,CDH10,LIMS1,PLEC,CADM2B |
| Adherens junctions interactions | CTNNA1,CADM2A,PVRL2L,CDH18A,CDH9,CTNND1,PTBP3,CDH17,CDH7,CDH6 |
Protein Function
CDH18 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH18 itself. We selected most functions CDH18 had, and list some proteins which have the same functions with CDH18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | EDEM2,S100A2,S100A10B,CAPN3,CASQ1B,ELTD1,PLCB2,PCDH2G6,CASQ1,LPCAT2 |
Interacting Protein
CDH18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH18.
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References
- Yoshimura, K; Meckel, KF; et al. Integrin alpha 2 Mediates Selective Metastasis to the Liver. CANCER RESEARCH 69:7320-7328(2009).
- Mackowiak, II; Gentile, LB; et al. E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors. VETERINARY JOURNAL 194:405-411(2012).
