CDH17
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Official Full Name
cadherin 17, LI cadherin (liver-intestine) -
Overview
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins.;The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a;transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal;tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral;absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological;organization of liver and intestine. Alternative splicing results in multiple transcript variants. -
Synonyms
CDH17;cadherin 17, LI cadherin (liver-intestine);cadherin-17;cadherin;HPT 1;LI cadherin;LI-cadherin;cadherin-16;HPT-1 cadherin;liver-intestine cadherin;human peptide transporter 1;intestinal peptide-associated transporter HPT-1;human intestina
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Chicken
- Zebrafish
- Cynomolgus
- HEK293
- C-His
- Wheat Germ
- E.coli
- Mammalian Cells
- Human Cells
- Mouse
- Yeast
- Non
- GST
- His
- His&T7
- Fc
- mFc
- His&Avi
- His&Myc
- His&Fc&Avi
Involved Pathway
CDH17 involved in several pathways and played different roles in them. We selected most pathways CDH17 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-Cell communication | CDH18,CDH12A,DSCAM,COL17A1A,CLDN20,CDH12,SKAP2,DSCAMA,CDH13,CLDN7 |
| Cell-cell junction organization | ANG,JUPA,CLDN7,CLDN3,CDH10A,CTNND1,CDH12A,CDH11,CDH9,CDH12 |
| Adherens junctions interactions | CDH5,CADM2B,CADM2A,CDH11,PTBP3,CDH10A,CDH18,CDH10,CDH12,CTNNA1 |
| Cell junction organization | PVRL2L,CDH13,COL17A1,CADM2,CLDN23,CDH9,CDH5,CDH6,CLDN16,CDH24 |
Protein Function
CDH17 has several biochemical functions, for example, calcium ion binding,proton-dependent oligopeptide secondary active transmembrane transporter activity,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH17 itself. We selected most functions CDH17 had, and list some proteins which have the same functions with CDH17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | SLC15A3,SLC6A18,SLC4A11,AQP1A.1,Slc4a2,CRABP1B,LCN2,SLC22A13,SLC4A1A,SLC5A8L |
| calcium ion binding | PLCD1,AMY2A,CAMKK2,SLC25A23,MMP19,ACTN3A,CAPS,S100A2,PCDH2AB5,SGCA |
| proton-dependent oligopeptide secondary active transmembrane transporter activity | SLC15A1 |
Interacting Protein
CDH17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH17 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH17.
Resources
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References
- Funakoshi, S; Shimizu, T; et al. BILL-Cadherin/Cadherin-17 Contributes to the Survival of Memory B Cells. PLOS ONE 10:-(2015).
- Lin, ZH; Zhang, C; et al. Targeting Cadherin-17 Inactivates Ras/Raf/MEK/ERK Signaling and Inhibits Cell Proliferation in Gastric Cancer. PLOS ONE 9:-(2014).
