CDC6
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Official Full Name
cell division cycle 6 homolog -
Overview
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the;initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It;localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The;subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.;Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional;control mechanism involving E2F proteins. -
Synonyms
CDC6;cell division cycle 6 homolog (S. cerevisiae);CDC6 (cell division cycle 6, S. cerevisiae) homolog , CDC6 cell division cycle 6 homolog (S. cerevisiae) , CDC18L;cell division control protein 6 homolog;p62(cdc6);CDC6-related protein;cdc18-relate
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC6-11018H | Recombinant Human CDC6, GST-tagged | E.coli | Human | GST | C-term-343a.a. | |
| CDC6-022H | Recombinant Human CDC6 Protein, His-tagged | E.coli | Human | His | Full L. |
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| CDC6-3152M | Recombinant Mouse CDC6 Protein | Mammalian Cell | Mouse | His |
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| CDC6-6781Z | Recombinant Zebrafish CDC6 | Mammalian Cell | Zebrafish | His |
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| CDC6-93H | Recombinant Human cell division cycle 6 homolog (S. cerevisiae) | E.coli | Human | Non | 260-563 a.a. |
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| CDC6-96H | Recombinant Human CDC6, GST-tagged | Wheat Germ | Human | GST |
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| CDC6-7647HCL | Recombinant Human CDC6 293 Cell Lysate | HEK293 | Human | Non |
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| CDC6-1493M | Recombinant Mouse CDC6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDC6-1493M-B | Recombinant Mouse CDC6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CDC6 involved in several pathways and played different roles in them. We selected most pathways CDC6 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CHEK1,TERF2IP,GADD45BA,GSK3AA,WRAP53,CLSPN,BUB1B,RANGAP1B,PIANP,TEX12 |
Protein Function
CDC6 has several biochemical functions, for example, ATP binding,kinase binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC6 itself. We selected most functions CDC6 had, and list some proteins which have the same functions with CDC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase binding | WWC2,DLG4,C2orf44,MOB4,JAKMIP2,MIDN,DGKQ,TRADD,CEBPB,TENC1 |
| ATP binding | GALK2,PLK2,STK19,UBE2D2A,TSSK3,CKMT1A,DDX3,ERBB4A,UBE2D2,MAPK8B |
| protein binding | GBAS,HNRNPM,PAX8,LEPROT,CARD11,PSRC1,PGAP2,KLC2,SCGB2A2,MYO6 |
| nucleotide binding | EEF1A1B,CSNK1G2A,FGFR1B,CHD8,SCAF8,WRNIP1,RAB32A,UBE2G1A,ACTB2,STK30 |
Interacting Protein
CDC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC6.
CDKN1A;CDT1;ORC5;CDK4;MCM3;CDKN2A;MCM2;CDK6;ORC1;ORC2;MCM10;ORC3;ORC6;Cdc6;EBNA1;UBB;MCM7
Resources
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References
- Buechler, S; et al. Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. BMC CANCER 9:-(2009).
- Di Paola, D; Rampakakis, E; et al. Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. NUCLEIC ACIDS RESEARCH 38:2314-2331(2010).
