CD69
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Official Full Name
CD69 antigen -
Overview
CD69 is a phosphorylated disulphide-linked dimmer composed of two chains of 27 kDa and 33 kDa, and also known as activation inducer molecule (AIM). CD69 is the earliest inducible surface antigen expressed on lymphocytes after T and B cell activation. CD69 is absent from resting lymphocytes (Sanchez-Madrid, 1995). Other cells, including epidermal Langerhans cells, natural killer (NK) cells, eosinophils, neutrophils, and platelets may also express CD69 (Poggi, 2002). In vitro studies have demonstrated a transient expression of CD69 on activated T cells. After activation, surface expression can be detected within 2-4 hours, reaching a maximum after 18-24 hours followed by a gradual decrease (Hara, 1986). CD69 is thus detectable prior to other activation antigens like CD25 and CD71. CD69 is believed to be involved in signal transduction, since cross-linking with anti-CD69 induces activation (Testi, 1989). -
Synonyms
CD69;CD69 antigen;early activation antigen CD69;Very Early Activation Antigen;AIM;VEA;AI452015;5830438K24Rik
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rhesus macaque
- Chicken
- Rat
- Mus musculus
- HEK293
- N-His
- Wheat Germ
- Mammalian Cells
- Insect Cells
- E.coli
- Human Cells
- In Vitro Cell Free System
- His
- His&Avi
- GST
- Non
- Fc
- hIgG4
- Myc&DDK
- Avi&His&Fc
- MBP&His&Avi
Involved Pathway
CD69 involved in several pathways and played different roles in them. We selected most pathways CD69 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CD69 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CD69 has several biochemical functions, for example, calcium ion binding,carbohydrate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD69 itself. We selected most functions CD69 had, and list some proteins which have the same functions with CD69. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HIST1H2AI,JMJD7,RAB43,Trf,NDRG1,DLG4,PQBP1,COPS6,MED23,SUV39H1 |
| transmembrane signaling receptor activity | GHRHRA,OR6K3,TLR9,NPR2,ERBB2,GPR98,OR2A4,IL27RA,TLR5,RYK |
| calcium ion binding | PCDH1G26,ADAMTS13,TPM4,ACTN4,NRXN1,PCDH2AA15,SYT12,PCDHA5,NECAB3,FKBP14 |
| carbohydrate binding | MAN2A1,CALR3,FCN3,CNTN1,CANX,SIGLEC8,GALNT7,GALNTL1,NOMO2,SIGLEC10 |
Interacting Protein
CD69 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD69 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD69.
TMEM190;secA2
Resources
Research Area
Myeloid Lineage MarkersNatural Killer Cells (NK Cells) Markers
Granulocyte Markers
Eosinophils
Neutrophils
Natural Killer T (NKT) Cells
T Cell Markers
CD Antigen (Granulocyte Markers)
Macrophage Marker CD Antigen
CD Antigen (Regulatory T Cells)
T Follicular Helper (Tfh) Cells
Related Services
Related Products
References
- Tomescu, C; Seaton, KE; et al. Innate Activation of MDC and NK Cells in High-Risk HIV-1-Exposed Seronegative IV-Drug Users Who Share Needles When Compared With Low-Risk Nonsharing IV-Drug User Controls. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:264-273(2015).
- Suzuki, S; Konnai, S; et al. Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:115-124(2015).
