CD53
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Official Full Name
Cd53 molecule -
Overview
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.;Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.;The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,;growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It;contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to;play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated;with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple;transcript variants encoding the same protein. -
Synonyms
CD53;Cd53 molecule;leukocyte surface antigen CD53;CD53 antigen;Leukocyte antigen (Ox-44);leukocyte antigen MRC OX-44;cell surface glycoprotein CD53;OX44;Ox-44;RATOX44
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Mus musculus
- Bovine
- Wheat Germ
- Mammalian Cells
- Human Cells
- HEK293
- Protein Conjugation
- In Vitro Cell Free System
- E.coli
- Non
- GST
- His
- Fc
- His&Fc
- mFc
- Myc&DDK
- His&GST
- His&Fc&Avi
Involved Pathway
CD53 involved in several pathways and played different roles in them. We selected most pathways CD53 participated on our site, such as IL-2 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL-2 Signaling pathway | NMI,CISH,SHB,ITM2BA |
Protein Function
CD53 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CD53 itself. We selected most functions CD53 had, and list some proteins which have the same functions with CD53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CD53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD53 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD53.
Resources
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References
- Todros-Dawda, I; Kveberg, L; et al. The Tetraspanin CD53 Modulates Responses from Activating NK Cell Receptors, Promoting LFA-1 Activation and Dampening NK Cell Effector Functions. PLOS ONE 9:-(2014).
- Ruiz-Mateos, E; Pelchen-Matthews, A; et al. CD63 is not required for production of infectious human immunodeficiency virus type 1 in human macrophages. JOURNAL OF VIROLOGY 82:4751-4761(2008).
