CCR6
-
Official Full Name
chemokine (C-C motif) receptor 6 -
Overview
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. -
Synonyms
CCR6;chemokine (C-C motif) receptor 6;C-C chemokine receptor type 6;CCR-6;KY411;Cmkbr6;CC-CKR-6
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Mus musculus
- HEK293
- Wheat Germ
- Mammalian Cells
- E.coli
- In Vitro Cell Free System
- Non
- His
- His&Flag
- His&Myc
- His&SUMO
- His&Fc&Avi
Involved Pathway
CCR6 involved in several pathways and played different roles in them. We selected most pathways CCR6 participated on our site, such as Beta defensins,Chemokine receptors bind chemokines,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL3L1,ELMO1,NRAS,CCL6,CXCR2,GNGT1,CXCR1,DOCK2,CXCL2,PRKCB |
| Class A/1 (Rhodopsin-like receptors) | PROK1,GRP,CCR1,HCRT,OPN1SW,CXCR6,QRFPR,SST1.1,ADRA2B,ADRB3 |
| Defensins | DEFB119,DEFA1,DEFB1,DEFB4A,DEFA6,DEFB125,DEFA3,DEFB129,DEFA5,ART1 |
| Cytokine-cytokine receptor interaction | IFNA1,KITLGA,TGFB2,CCL8,PPBP,GM10591,VEGFB,GH2,TNFSF13,IL8L1 |
| G alpha (i) signalling events | SSTR1,RLN3,TAS2R7,CNR2,SST1.1,DRD4,PENKA,CXCL11.8,GPR18,AGTR2 |
| GPCR downstream signaling | FGD4A,CCL19A.2,TRPC7,OR52J3,GCGB,MLN,RLN3A,ANXA1B,OR7D2,OPN1LW2 |
| Beta defensins | DEFB116,DEFB121,DEFB119,DEFB104A,DEFB103A,DEFB125,DEFB4A,DEFB106A,DEFB1,DEFB129 |
| Chemokine receptors bind chemokines | ACKR4,CCR5,CXCL11.8,CX3CR1,CCR7,CCR3,CXCR6,CCBP2,CCL19A.2,CCRL2 |
Protein Function
CCR6 has several biochemical functions, for example, C-C chemokine receptor activity,chemokine receptor activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR6 itself. We selected most functions CCR6 had, and list some proteins which have the same functions with CCR6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | IL18R1,PVRL3,NOTCH1A,ADIPOR1B,ATRN,LILRA3,CNTNAP1,NPC1,GP6,CSF2RB |
| chemokine receptor activity | RGRB,CCR9,CCR3,ACKR4,XCR1,CXCR7B,GPR17,CXCR1,CXCR4A,ACKR3B |
| C-C chemokine receptor activity | CCR6A,GPR75,CCR10,CCR3,CCR1,CCBP2,CCR7,CCR5,CCR9,CCR8 |
Interacting Protein
CCR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR6.
Resources
Research Area
gamma delta T CellsNatural Killer T (NKT) Cells
Regulatory T Cells (Tregs)
T Cell Migration
CC Chemokine Receptors
Related Services
Related Products
References
- Tan, JF; Jin, XF; et al. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. ONCOLOGY REPORTS 33:1512-1518(2015).
- Bulati, M; Buffa, S; et al. Double Negative (IgG(+)IgD(-)CD27(-)) B Cells are Increased in a Cohort of Moderate-Severe Alzheimer's Disease Patients and Show a Pro-Inflammatory Trafficking Receptor Phenotype. JOURNAL OF ALZHEIMERS DISEASE 44:1241-1251(2015).
