CCR4
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Official Full Name
chemokine (C-C motif) receptor 4 -
Overview
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. -
Synonyms
CCR4;chemokine (C-C motif) receptor 4;LESTR;Sdf1r;CHEMR1;Cmkbr4;C-C CKR-4;C-C chemokine receptor type 4;fusin;chemokine (C-C) receptor 4;leukocyte-expressed seven-transmembrane-domain receptor
Recombinant Proteins
- Human
- Rhesus macaque
- Dog
- Mus musculus
- HEK293
- Wheat Germ
- Mammalian Cells
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
CCR4 involved in several pathways and played different roles in them. We selected most pathways CCR4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CCR4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCR4 itself. We selected most functions CCR4 had, and list some proteins which have the same functions with CCR4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CCR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR4.
Resources
Research Area
Cancer Drug TargetsRegulatory T Cells (Tregs)
T Cell Migration
CC Chemokine Receptors
Related Services
Related Products
References
- Yamauchi, J; Coler-Reilly, A; et al. Mogamulizumab, an Anti-CCR4 Antibody, Targets Human T-Lymphotropic Virus Type 1-infected CD8(+) and CD4(+) T Cells to Treat Associated Myelopathy. JOURNAL OF INFECTIOUS DISEASES 211:238-248(2015).
- Ni, X; Jorgensen, JL; et al. Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome. CLINICAL CANCER RESEARCH 21:274-285(2015).
