CCNH
-
Official Full Name
cyclin H -
Overview
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants. -
Synonyms
CCNH;cyclin H;cyclin-H;CAK complex subunit;CDK activating kinase complex subunit;cyclin dependent kinase activating kinase complex subunit;MO15 associated protein;p34;p37;MO15-associated protein;CDK-activating kinase complex subunit;cyclin-depe
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Cynomolgus
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CCNH involved in several pathways and played different roles in them. We selected most pathways CCNH participated on our site, such as Basal transcription factors,Nucleotide excision repair,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | MASTL,RAD21B,NEK7,CDC25C,SMC3,SMC1B,NCAPG2,CENPJ,LIN9,YWHAE1 |
| Basal transcription factors | ERCC2,GTF2H5,GTF2F2A,TAF9B,GTF2H2C,GTF2A1L,TAF7,GTF2H2,TBPL1,CDK7 |
| Nucleotide Excision Repair | ERCC6,RPA1,GTF2H3,ERCC8,RAD23A,POLE3,NFRKB,YY1,XPC,GTF2H1 |
Protein Function
CCNH has several biochemical functions, for example, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNH itself. We selected most functions CCNH had, and list some proteins which have the same functions with CCNH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SERPINC1,WFIKKN2,ITIH2,SERPINA3K,TFPIA,SERPINA1,EPPIN,SERPINB3,WFDC5,SERPINB8 |
Interacting Protein
CCNH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNH here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNH.
GOLGA2;CDK2;CDK7;SSSCA1;PSMA1
Resources
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References
- Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).
- Park, KS; Bayles, I; et al. Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response. JOURNAL OF IMMUNOLOGY 193:4663-4674(2014).
