CBX3
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Official Full Name
chromobox homolog 3 -
Overview
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5 UTR, have been found for this gene.[provided by RefSeq, Mar 2011] -
Synonyms
CBX3;chromobox homolog 3;HECH;HP1-GAMMA;HP1Hs-gamma;chromobox protein homolog 3;HP1 gamma homolog;modifier 2 protein;heterochromatin-like protein 1;heterochromatin protein HP1 gamma;heterochromatin protein 1 homolog gamma;chromobox homolog 3 (HP1 gamma homolog, Drosophila)
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
Involved Pathway
CBX3 involved in several pathways and played different roles in them. We selected most pathways CBX3 participated on our site, such as Diurnally regulated genes with circadian orthologs,Gene Expression,RNA Polymerase I Chain Elongation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA Polymerase I Transcription | MBD3B,CBX3A,PTRF,GATAD2A,MBD3A,MTA2,TAF1B,EFCAB11,CD3EAP,MTA3 |
| Diurnally regulated genes with circadian orthologs | EIF4G2,AZIN1,ZFR,NR1D2,QK,SF3A3,PURA,RBPMS,G0S2,DAZAP2 |
| RNA Polymerase I Chain Elongation | EFCAB11,CD3EAP,TAF1C,TAF1B,UBTF,TAF1A,TAF1D,CBX3A |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | POU2F1B,GATAD2AB,SNAPC2,BRF1,SNAPC5,MBD3B,CHD4A,PTRFB,CHD4,MBD3A |
| Gene Expression | NFIX,ZFP37,ZNF224,SPCS3,TSEN54,ZNF75A,SUPT5H,GATAD2AB,ZNF543,SETB |
Protein Function
CBX3 has several biochemical functions, for example, enzyme binding,histone methyltransferase binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX3 itself. We selected most functions CBX3 had, and list some proteins which have the same functions with CBX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CC2D2A,TWF2,CTNNA3,LPXN,TTC33,PKD2L1,NME3,SEPT4,GNGT1,RCC1 |
| protein domain specific binding | BHLHE40,KCNN2,TWIST2,TJP1,PLG,HNRNPM,PRKCZ,HIST1H4B,ICA1L,CHMP1B |
| identical protein binding | EWSR1,TYROBP,LRP6,DYNLT1F,STIM1,C1QTNF6,SCUBE1,S100A4,CLDN1,RCAN1 |
| enzyme binding | CDK19,TULP3,YWHAH,GOLPH3,PCCA,FAM84B,HINFP,PGR,SNRPD3,BTG1 |
| histone methyltransferase binding | NOP56,PRDM4,CBX1 |
Interacting Protein
CBX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX3.
TRIM28;HIST1H3D;LBR;Mis12;Mad2l2
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References
- Ren, CY; Morohashi, K; et al. Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. CHEMISTRY & BIOLOGY 22:161-168(2015).
- Tsui, KH; Lin, LT; et al. Gene expression of cumulus cells in women with poor ovarian response after dehydroepiandrosterone supplementation. Taiwanese Journal of Obstetrics & Gynecology 53:559-565(2014).
