CASC4
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Official Full Name
cancer susceptibility candidate 4 -
Overview
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. -
Synonyms
CASC4;cancer susceptibility candidate 4;protein CASC4;DKFZp459F1927;H63;Cancer susceptibility candidate gene 4 protein;CASC4_HUMAN;Gene associated with HER-2/neu overexpression;MGC74708
Recombinant Proteins
- Human
- Chicken
- Mouse
- Bovine
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- Avi&His&Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CASC4-0409H | Recombinant Human CASC4 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CASC4-2270C | Recombinant Chicken CASC4 | Mammalian Cells | Chicken | His |
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| CASC4-2742M | Recombinant Mouse CASC4 Protein | Mammalian Cells | Mouse | His |
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| CASC4-7843HCL | Recombinant Human CASC4 293 Cell Lysate | HEK293 | Human | Non |
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| CASC4-1235M | Recombinant Mouse CASC4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&His&Fc |
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| CASC4-1235M-B | Recombinant Mouse CASC4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CASC4-2904HF | Recombinant Full Length Human CASC4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 436 amino acids |
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| RFL12938BF | Recombinant Full Length Bovine Protein Casc4(Casc4) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length (1-380) |
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Involved Pathway
CASC4 involved in several pathways and played different roles in them. We selected most pathways CASC4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CASC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CASC4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CASC4 itself. We selected most functions CASC4 had, and list some proteins which have the same functions with CASC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CASC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASC4.
Resources
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References
- Chiang, HC; Wang, CK; et al. Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract. RESPIRATION 84:319-326(2012).
- Melchor, L; Saucedo-Cuevas, LP; et al. Comprehensive characterization of the DNA amplification at 13q34 in human breast cancer reveals TFDP1 and CUL4A as likely candidate target genes. BREAST CANCER RESEARCH 11:-(2009).
