CAMLG
-
Official Full Name
calcium modulating ligand -
Overview
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. -
Synonyms
CAMLG;calcium modulating ligand;calcium signal-modulating cyclophilin ligand;calcium modulating cyclophilin ligand;calcium signal modulating cyclophilin ligand;CAML;cyclophilin B binding protein;MGC163197;cyclophilin B-binding protein;calcium-modulating cyclophilin ligand;calcium-signal modulating cyclophilin ligand;AI385748
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&GST
Involved Pathway
CAMLG involved in several pathways and played different roles in them. We selected most pathways CAMLG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CAMLG has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMLG itself. We selected most functions CAMLG had, and list some proteins which have the same functions with CAMLG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ANXA4,KTI12,PRKAR2AA,DLG1,HNRNPM,NOTCH2NL,PFKM,EGLN3,KLHDC5,SLC30A8 |
Interacting Protein
CAMLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMLG here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMLG.
KCNA2;TNFRSF13B;EGFR;IER3;mexB;TRAF5;TRAF6;MYD88
Resources
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References
