CAMK4
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Official Full Name
calcium/calmodulin-dependent protein kinase IV -
Overview
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. -
Synonyms
CAMK4;calcium/calmodulin-dependent protein kinase IV;calcium/calmodulin-dependent protein kinase type IV;brain Ca++ calmodulin dependent protein kinase type IV;calcium/calmodulin dependent protein kinase type IV catalytic chain;CAM kinase IV;CAM kin
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Mouse
- Insect Cells
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- E.coli
- Insect Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Insect (sf21)
- GST
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CAMK4 involved in several pathways and played different roles in them. We selected most pathways CAMK4 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Long-term potentiation | MAPK1,PLCB2,BRAF,PRKCG,PPP3CC,HRAS,CALML5,RAF1,PPP3CA,RPS6KA2 |
| Osteoclast differentiation | MAPK3,AKT1,GAB2,PIK3R3,PIK3CD,LILRA5,SIRPG,IKBKB,IFNB1,IL1B |
| Alcoholism | H2AFB3,HIST3H2BB-PS,HIST2H3A,HIST1H4A,PDYN,HIST1H2BD,GNAS,HIST1H2BI,SOS1,HIST1H2BF |
| Cholinergic synapse | CREB3L4,GNGT2,ITPR1,PLCB4,CREB3L2,CREB5,KRAS,SLC5A7,CAMK2A,AKT2 |
| Oxytocin signaling pathway | MYLK2,PRKAB1,PPP1CC,CCND1,PRKAA1,CACNA2D4,MEF2C,HRAS,PLA2G4D,GNAI2 |
| cAMP signaling pathway | HCAR3,PIK3CB,GRIN2B,PDE3B,CALML5,RAP1A,PPP1CB,PLD1,PLD2,HTR1E |
| Neurotrophin signaling pathway | PIK3CG,RPS6KA2,NGF,CAMK2G,ATF4,PLCG1,TRP53,MAPK9,BAD,TP53 |
| Aldosterone synthesis and secretion | PLCB1,CALM4,PLCB4,DDX1,ATF2,ADCY1,CREB3L3,CACNA1G,AGTR1,ADCY3 |
| Calcium signaling pathway | MYLK,PLCD3A,HRH2,STIM1A,SLC8A4A,CACNA1BA,P2RX3B,CALM,SLC25A6,PTGER3 |
Protein Function
CAMK4 has several biochemical functions, for example, ATP binding,calcium-dependent protein serine/threonine kinase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK4 itself. We selected most functions CAMK4 had, and list some proteins which have the same functions with CAMK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | KCNQ3,MYO3A,GRIN1,SNTB2,INVS,PPP3R1,KCNN1,NOS2,CAMK1D,PDE1B |
| calcium-dependent protein serine/threonine kinase activity | MKNK1,MAPKAPK2B,CAMK1GB,MKNK2B,MAPKAPK2A,MKNK2,MAPKAPK5,MKNK2A,MAPKAPK2,DCX |
| calmodulin-dependent protein kinase activity | CAMKK1,DCX,CAMK1G,CAMK1D,MAPKAPK2,CAMK2D1,MKNK2A,MYLK3,CAMK2B1,DAPK2A |
| ATP binding | PRKCB,MARK4,HSPE1,TTL,CCT5,MYO1G,PAPSS1,DGKD,VMHCL,ATP1A3B |
Interacting Protein
CAMK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK4.
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References
- Sugiyama, Y; Murao, K; et al. Calcium/calmodulin-dependent protein kinase IV involvement in the pathophysiology of glucotoxicity in rat pancreatic beta-cells. METABOLISM-CLINICAL AND EXPERIMENTAL 60:145-153(2011).
- Blanquet, PR; Mariani, J; et al. Temporal assessment of histone H3 phospho-acetylation and casein kinase 2 activation in dentate gyms from ischemic rats. BRAIN RESEARCH 1302:10-20(2009).
