CAMK2D
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Official Full Name
calcium/calmodulin-dependent protein kinase II delta -
Overview
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns. -
Synonyms
CAMK2D;calcium/calmodulin-dependent protein kinase II delta;calcium/calmodulin dependent protein kinase (CaM kinase) II delta , CAMKD;calcium/calmodulin-dependent protein kinase type II subunit delta;CaMK-II delta subunit;caMK-II subunit delta;CaM-k
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Insect Cells
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Sf21 Cells
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Myc
- His&Fc&Avi
Involved Pathway
CAMK2D involved in several pathways and played different roles in them. We selected most pathways CAMK2D participated on our site, such as ErbB signaling pathway,Calcium signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | ATP4A,ATP1A3,KCNJ2,Slc4a2,ATP1B2,KCNE2,PRKACG,ATP1A2,CAMK2A,PRKCB |
| Olfactory transduction | OLFR477,CALM3,OR2C1,CALML5,OLFR5,OR12D2,RGS2,CAMK2A,OR10J1,OR6B2 |
| Adrenergic signaling in cardiomyocytes | PRKACG,AKT2,PPP2R2BB,CALM1,CALM1A,PPP1R1A,PRKACAB,ACTC1,CACNG7A,PIK3CB |
| Circadian entrainment | PER3,GUCY1A3,PRKACG,GNG8,PLCB3,GRIA2,RYR2,GNGT2,PRKCA,CAMK2B |
| Aldosterone synthesis and secretion | CYP11B2,ADCY6,PLCB1,CYP21A2,ITPR2,SLC14A2,LDLR,GNA11,SCARB1,CREB3L3 |
| Wnt signaling pathway | WNT8A,CSNK1A1L,FZD3B,NKD1,SKP1,PLCB3,WIF1,WNT11R,CUL1A,PRKCG |
| cAMP signaling pathway | MAPK9,ATP1A3,CALM3,PAK1,PDE4D,AKT2,GHRL,TSHR,RYR2,RAF1 |
| Insulin secretion | FFAR1,CAMK2A,SLC2A1,CAMK2G,KCNMA1,GIP,ATP1B3,GNAQ,GCG,ATP1B4 |
| Long-term potentiation | RAP1B,RPS6KA1,PPP1CA,RAF1,GRIA2,GRIN2B,CALM1,ITPR3,CALML5,PLCB2 |
Protein Function
CAMK2D has several biochemical functions, for example, ATP binding,calmodulin binding,calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2D itself. We selected most functions CAMK2D had, and list some proteins which have the same functions with CAMK2D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| titin binding | ANKRD23,ANKRD1,ACTN2,ANKRD1B,MYBPC3,OBSCN,SLC14A2,CAPN3,MYBPC1,CALM1 |
| sodium channel inhibitor activity | PCSK9,NEDD4L,SCN1B,NEDD4,SLC14A2 |
| calmodulin-dependent protein kinase activity | SLC14A2,MKNK1,MKNK2A,CAMK2B,NETO2,CAMK2B1,CAMK2D1,PNCK,DCX,MAPKAPK5 |
| ATP binding | PAPOLB,DYNC1LI1,BMPR2B,MOS,DNAH11,GLULC,UBE2L3B,ITPKA,IKBKAP,UBE2M |
| calmodulin binding | AEBP1,PPP3R1,EPB41B,CDK5RAP2,SLC9A1,SNTA1,MYO5B,MYO7A,MKNK2,ATP2B1 |
| protein binding | TRAFD1,PPFIA4,RAP1B,NOL11,OLFM2,KPNA6,ATP2C2,DNAJC7,DYNC2LI1,ORC4L |
| nitric-oxide synthase binding | ACTB,CAV3,CALM1,SCN5A,SLC6A4,CALM3,CD74,CALM2,NOS1AP,DMD |
| protein homodimerization activity | TBX18,HOMER2,MAP3K5,ERBB4,ACCS,DMRTC1C2,TSC2,PDE2A,MCL1B,ENO3 |
| protein serine/threonine kinase activity | CSNK1D,PLK2,ACVRL1,PAK6,DCLK2,STK35,CSNK1G1,PKN1B,RIOK3,TESK1 |
Interacting Protein
CAMK2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2D here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2D.
SCN5A;TNPO2;DNAL4
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References
- Hidalgo, CG; Chung, CS; et al. The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKII delta) phosphorylates cardiac titin's spring elements. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 54:90-97(2013).
- Chen, QW; Edvinsson, L; et al. Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells. BMC CELL BIOLOGY 10:-(2009).
