CACNG1
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Official Full Name
calcium channel, voltage-dependent, gamma subunit 1 -
Overview
Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). -
Synonyms
CACNG1;calcium channel, voltage-dependent, gamma subunit 1;CACNLG;voltage-dependent calcium channel gamma-1 subunit;Dihydropyridine sensitive L type skeletal muscle calcium channel gamma subunit;skeletal muscle calcium channel subunit gamma;CACNLG calcium channel neuronal dihydrpyridine sensitive gamma subunit;Calcium channel L type gamma polypeptide;Calcium channel voltage dependent gamma subunit 1;CCG1_HUMAN;Dihydropyridine sensitive L type skeletal muscle calcium channel subunit gamma;Dihydropyridine-sensitive L-type;fb43f02;fi19g08;L type calcium channel gamma polypeptide;MGC117703;Voltage dependent calcium channel gamma 1 subunit 2;wu:fb43f02;zgc:55364;L-type calcium channel gamma polypeptide;neuronal dihydropyridine-sensitive calcium channel gamma subunit;dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Recombinant Proteins
- Rat
- Mouse
- Chicken
- Human
- Sus scrofa (Pig)
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Bovine
- Mammalian Cell
- In vitro E. coli expression system
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
CACNG1 involved in several pathways and played different roles in them. We selected most pathways CACNG1 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCG,CACNA2D2,ITGA2B,CACNG2,CACNA2D3,CACNA2D4,ITGB1,TCF7L2,ITGA6,ITGB4 |
| Cardiac muscle contraction | COX5B,COX7A2A,ATP1B2A,TPMA,SLC8A1,COX4I1,ACTC1A,COX6A2,ATP1B4,CACNB2A |
| MAPK signaling pathway | MAP3K7,MAPK10,MAP3K1,NLK1,HRASA,MAPK3,TRAF6,CACNA2D1,FGF4,RPS6KAL |
| Dilated cardiomyopathy | ITGA5,CACNA2D3,ITGA10,TGFB3,SGCA,CACNG2,DAG1,ITGA7,PLN,CACNG4 |
| Oxytocin signaling pathway | ROCK2,PLCB1,CACNA2D3,CALM1,PRKAB1,KCNJ14,PRKACB,RYR3,GNAQ,PLA2G4D |
| Hypertrophic cardiomyopathy (HCM) | TPM3,PRKAB2,CACNG4,CACNG6,DAG1,PRKAB1,MYH7,TGFB3,CACNG8,CACNB2 |
| Adrenergic signaling in cardiomyocytes | ATP2A2,PLCB1,CREB5,ADRB2,AKT3A,MAPK11,PPP2R5E,PRKACG,CACNG1A,MYL3 |
Protein Function
CACNG1 has several biochemical functions, for example, protein binding,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG1 itself. We selected most functions CACNG1 had, and list some proteins which have the same functions with CACNG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AHCYL2,RTN4RL1B,TIMM44,FCGR2A,UFD1L,ADORA2A,ORMDL3,H2-KE2,C4orf26,RABL2A |
| voltage-gated calcium channel activity | CACNB4A,CACNA1C,CACNA1BA,CACNB2,CACNG6,TMC1,CACNG3,CACNB3A,GAS6,CACNG8A |
Interacting Protein
CACNG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG1.
a8ka83_human
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References
- Endoh, T; Sato, D; et al. Galanin inhibits calcium channels via G alpha(i)-protein mediated by GalR1 in rat nucleus tractus solitarius. BRAIN RESEARCH 1229:37-46(2008).
- Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
