CACNB1
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Official Full Name
calcium channel, voltage-dependent, beta 1 subunit -
Overview
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Calcium channel, voltage-dependent, β1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel β subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the α1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. -
Synonyms
CACNB1;calcium channel, voltage-dependent, beta 1 subunit;CACNLB1;voltage-dependent L-type calcium channel subunit beta-1;calcium channel, L type, beta 1 polypeptide;calcium channel voltage-dependent subunit beta 1;dihydropyridine-sensitive L-type,
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mouse
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CACNB1 involved in several pathways and played different roles in them. We selected most pathways CACNB1 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF11,FGF20B,ACVR1C,PPP3R1B,MRAS,PAK2A,RASA1,PPP3R2,FGF6,RAP1B |
| Cardiac muscle contraction | ATP1B2,ATP1B3B,UQCRH,COX5A,UQCR10,CACNG4,MYH15,COX7A2,MYL4,ATP1A2 |
| Dilated cardiomyopathy | CACNG4,CACNG7,TGFB3,PRKACA,ITGA2,CACNB2,LMNA,SGCD,ITGA3,ITGB4 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNB3,DMD,ACTN4,ITGB8,SGCA,CACNG8,DES,CACNG6,EMD,ACTN2 |
| Adrenergic signaling in cardiomyocytes | SCN1BA,RAPGEF4,CALM2,AGTR1,KCNE1,MYH7,NETO2,ADRA1BB,PIK3CG,ATP1B2 |
| Oxytocin signaling pathway | CAMK2B,ROCK1,CACNG1,MAPK3,GNAI3,MYL9,FOS,CCND1,NFATC4,MAPK1 |
| Hypertrophic cardiomyopathy (HCM) | TTN,CACNG4,Itga10&Itgb1,CACNB3,ITGA2,LAMA2,MYL2,ACTC1,ITGB7,MYL3 |
Protein Function
CACNB1 has several biochemical functions, for example, high voltage-gated calcium channel activity,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB1 itself. We selected most functions CACNB1 had, and list some proteins which have the same functions with CACNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| high voltage-gated calcium channel activity | CACNA1BA,CACNB2B,CACNB3A,CACNA1B,CACNA1C,CACNB4B,CACNB3,CACNB2A,CACNB4A,CACNA1SB |
| voltage-gated calcium channel activity | CACNA2D1,CATSPER1,CACNB2A,GRM7,NCS1,CACNA1SB,CACNG1A,CACNA1D,CACNG8A,CACNA2D4 |
Interacting Protein
CACNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB1.
GEM;ATN1
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References
- Gaber, EM; Jayaprakash, P; et al. Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca2+transport in Goto-Kakizaki type 2 diabetic rat heart. EXPERIMENTAL PHYSIOLOGY 99:881-893(2014).
- Salem, KA; Adrian, TE; et al. Shortening and intracellular Ca2+in ventricular myocytes and expression of genes encoding cardiac muscle proteins in early onset type 2 diabetic Goto-Kakizaki rats. EXPERIMENTAL PHYSIOLOGY 97:1281-1291(2012).
