CACNA1F
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Official Full Name
calcium channel, voltage-dependent, L type, alpha 1F subunit -
Overview
This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants of the gene described here have been observed but have not been thoroughly characterized. Mutations in this gene have been shown to cause incomplete X-linked congential stationary night blindness type 2 (CSNB2). -
Synonyms
CACNA1F;calcium channel, voltage-dependent, L type, alpha 1F subunit;AIED, Aland island eye disease (Forsius Eriksson ocular albinism, ocular albinism type 2) , CSNB2;voltage-dependent L-type calcium channel subunit alpha-1F;Cav1.4;COD4;CORDX3;CSNB2A;CSNBX2;JM8;JMC8;OA2;CACNA 1F;CACNAF;CACNAF1;Calcium channel voltage dependent alpha 1F subunit;Calcium channel voltage dependent L type alpha 1F subunit;Cav1.4alpha1;COD 3;COD3;CORDX 3;CORDX;CSNBX 2;JM 8;JMC 8;Voltage ated calcium channel subunit alpha Cav1.4;Voltage ependent L ype calcium channel subunit alpha F;OTTHUMP00000024299;OTTHUMP00000032032;OTTHUMP00000216983;voltage gated calcium channel alpha 1F subunit;voltage-gated calcium channel subunit alpha Cav1.4;Aland island eye disease (For;AIED;CSNB2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CACNA1F-0266H | Recombinant Human CACNA1F Protein, GST-Tagged | Wheat Germ | Human | GST |
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Involved Pathway
CACNA1F involved in several pathways and played different roles in them. We selected most pathways CACNA1F participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
CACNA1F has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1F itself. We selected most functions CACNA1F had, and list some proteins which have the same functions with CACNA1F. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
CACNA1F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1F here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1F.
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References
- Liu, XN; Kerov, V; et al. Dysregulation of Ca(v)1.4 channels disrupts the maturation of photoreceptor synaptic ribbons in congenital stationary night blindness type 2. CHANNELS 7:514-523(2013).
- Zheng, LJ; Yan, YL; et al. Retinal horizontal cells reduced in a rat model of congenital stationary night blindness. NEUROSCIENCE LETTERS 521:26-30(2012).
