CACNA1D
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Official Full Name
Calcium Channel, Voltage-Dependent, L Type, Alpha 1D Subunit -
Overview
Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarisation. They regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Voltage-gated calcium channels are formed from four or five distinct subunits; the alpha-subunit is the largest subunit and incorporates the voltage sensor, conduction pore and gating apparatus. Using pharmacological and electrophysiological techniques, at least 6 types of voltage-gated channels have been identified: L, N, P, Q, R and T, which are grouped into three families. Cav1.x are high-voltage-activated dihydropyridine-sensitive (L-type), Cav2.x are high-voltage-activateddihydropyridine-insensitive (N-, P- Q- and R-types) and Cav3.x are low-voltage-activated channels (T-type). -
Synonyms
Cacna1d;calcium channel, voltage-dependent, L type, alpha 1D subunit;C79217;Cchl1a;D-LTCC;Cchl1a2;Cacnl1a2;8430418G19Rik;voltage-dependent L-type calcium channel subunit alpha-1D;alpha 1 E;Cav1.3alpha1;calcium channel, L type, alpha-1 polypeptide;voltage-gated calcium channel subunit alpha Cav1.3
Recombinant Proteins
- Rat
- Chicken
- Human
- Mammalian Cell
- E.coli
- E. coli
- HEK293
- His
- N-His-GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CACNA1D-1062R | Recombinant Rat CACNA1D Protein | Mammalian Cell | Rat | His |
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| CACNA1D-6591C | Recombinant Chicken CACNA1D | Mammalian Cell | Chicken | His |
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| CACNA1D-0466H | Recombinant Human CACNA1D Protein (Met1-Lys163), N-His-tagged | E.coli | Human | His | Met1-Lys163 |
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| CACNA1D-352H | Recombinant Human CACNA1A protein, His-GST-tagged | E. coli | Human | N-His-GST | Met1~Gly95 |
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| CACNA1D-353H | Recombinant Human CACNA1D protein, His-tagged | E. coli | Human | His | Lys1561-Val1780 |
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| CACNA1D-726R | Recombinant Rat CACNA1D Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CACNA1D-726R-B | Recombinant Rat CACNA1D Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CACNA1D involved in several pathways and played different roles in them. We selected most pathways CACNA1D participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | ATF4,CACNA2D2,ATP1A3,ATP1B2,PPP2R3A,GNAS,PLCB4,PRKACG,MYL4,PIK3R3B |
| MAPK signaling pathway | CD14,CDC42,MEF2CB,PRKCBA,MOS,PPM1BA,Casp3,MAPK6,FGFR3,HSP70L |
| Cardiac muscle contraction | ATP1B1,ATP1B2,MYH15,TPM4B,SLC8A1,UQCR10,CACNB2A,UQCRC2A,UQCR11,ATP1A1 |
| GnRH signaling pathway | ELK1,SOS1,GNA11B,CAMK2D1,CAMK2D,PRKCD,MAPK1,PLA2G4AA,GNRHR2,CAMK2G |
| Vascular smooth muscle contraction | AGTR1A,GNA11A,NPR1,CACNA1DA,PPP1CAB,PLA2G2D,RHOA,RAF1B,PPP1R14AB,GNA12A |
| Calcium signaling pathway | ADRA1BB,STIM2,PDE1C,GNA15.1,SLC8A1A,ADRB3A,PLCB1,ATP2B1,ADORA2A,RYR1 |
Protein Function
CACNA1D has several biochemical functions, for example, metal ion binding,voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1D itself. We selected most functions CACNA1D had, and list some proteins which have the same functions with CACNA1D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | HDAC5,ZBED5,CSNK2B,B4GALT5,ZNF524,THAP10,PVALB6,PDE3A,ARHGEF28,NRP1B |
| voltage-gated calcium channel activity | CACNG4,CACNG3,RYR1,CACNB4B,CACNA2D1,CATSPER1,CALHM1,CACNG8,CACNB3A,CACNB4A |
Interacting Protein
CACNA1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1D here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1D.
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References
- Romero, PJ; Romero, EA; et al. Voltage-dependent calcium channels in young and old human red cells. CELL BIOCHEMISTRY AND BIOPHYSICS 46:265-276(2006).
- Cohen, RM; Foell, JD; et al. Unique modulation of L-type Ca2+ channels by short auxiliary beta(1d) subunit present in cardiac muscle. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 288:H2363-H2374(2005).
