CACNA1C

  • Official Full Name

    Calcium Channel, Voltage-Dependent, L Type, Alpha 1C Subunit

  • Overview

    Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some references suggest it is related to bipolar disease as well.

  • Synonyms

    CACNA1C;Cav1.2 Calcium Channel;calcium channel, voltage-dependent, L type, alpha 1C subunit;TS;CACH2;CACN2;CaV1.2;CCHL1A1;CACNL1A1;MGC120730;voltage-dependent L-type calcium channel subunit alpha-1C;DHPR, alpha-1 subunit;calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit;calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle;voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*;Voltage-gated calcium channel subunit alpha Cav1.2;OTTHUMP00000196730;OTTHUMP00000196731;OTTHUMP00000196732;OTTHUMP00000196733;OTTHUMP00000196734;OTTHUMP00000196735;OTTHUMP00000196736;OTTHUMP00000196737;OTTHUMP00000196738;OTTHUMP00000196739;OTTHUMP00000196740;OTTHUMP00000196741;OTTHUMP00000196742;OTTHUMP00000196743;OTTHUMP00000196744;OTTHUMP00000196745;OTTHUMP00000196746;OTTHUMP00000196747;OTTHUMP00000196748;OTTHUMP00000196749;OTTHUMP00000196750;OTTHUMP00000196751;OTTHUMP00000238277;OTTHUMP00000238278;OTTHUMP00000238279

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Guinea pig
  • Chicken
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • In vitro E. coli expression system
  • E. coli
  • E.coli expression system
  • GST
  • His&T7
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
CACNA1C-0264H Recombinant Human CACNA1C Protein, GST-Tagged Wheat Germ Human GST
Cacna1c-1423M Recombinant Mouse Cacna1c protein, His & T7-tagged E.coli Mouse His&T7 Ser1978~Leu2139
CACNA1C-9399Z Recombinant Zebrafish CACNA1C Mammalian Cell Zebrafish His
CACNA1C-01G Recombinant Guinea pig CACNA1C Full Length Transmembrane protein, His-tagged In vitro E. coli expression system Guinea pig His Full L. 1-169aa
CACNA1C-117H Recombinant Human CACNA1C protein, His-tagged E. coli Human His Glu431-Asn510
RFL11969GF Recombinant Full Length Chicken Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length (1-177)
RFL29137CF Recombinant Full Length Guinea Pig Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C(Cacna1C) Protein, His-Tagged E.coli expression system Guinea pig His Full L. Full Length (1-169aa)

    Involved Pathway

    CACNA1C involved in several pathways and played different roles in them. We selected most pathways CACNA1C participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adrenergic signaling in cardiomyocytes CACNG1A,CALML3,ADRB2B,ATP1B1B,ADRB3B,CACNG7,PPP2R5EA,GNAI3,CALM3,CREB1A
    Calcium signaling pathway CACNA1DA,MLCK2,VDAC2,P2RX6,PPIFA,AKR1C1,NOS2,BDKRB2,PDGFRA,PRKCBA
    Cardiac muscle contraction MYH7,CACNG2,CACNG8,ACTC1,TPM2,ATP2A2,CACNA2D3,CACNB3A,TPM1,FXYD2
    GnRH signaling pathway ADCY1B,MAPK1,CALM3A,CDC42,GNA11,PLA2G4D,HBEGFA,EGFRA,NRAS,GRB2A
    Vascular smooth muscle contraction PLCB2,PLA2G12A,PLA2G4F,PPP1CAA,CALD1B,GNAS,ADRA1BB,RHOAC,KCNMB1,MYL9A
    MAPK signaling pathway MAPKAPK5,RELB,GNA12A,PRKACAB,TGFBR1B,RAP1AA,FGF11,FGF20,HSPA6,GADD45G

    Protein Function

    CACNA1C has several biochemical functions, for example, calcium channel activity,high voltage-gated calcium channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1C itself. We selected most functions CACNA1C had, and list some proteins which have the same functions with CACNA1C. You can find most of the proteins on our site.

    Function Related Protein
    ion channel activity TRPC4A,HTR3B,TRPC6A,KCNV2,GRIN2BB,ASIC4,KCNH5A,GRIA4A,KCNB2,KCNH2A
    high voltage-gated calcium channel activity CACNB3,CACNB2A,CACNB3A,CACNA1BA,CACNB4A,CACNB2B,CACNA1DA,CACNA1SA,CACNA1SB,CACNB1
    voltage-gated calcium channel activity CACNG8,CACNB2,CACNG2A,CACNA1BA,CACNG3,CACNG7A,CACNB2A,OPRM1,IL1RAPL1,ATP6V0CB
    calcium channel activity MCU,TRPC5A,P2RX1,TRPC2B,TRPC1,CACNA1DA,PDE2A,CACNA1SA,CATSPER2,TRPV6
    voltage-gated ion channel activity ANO6,CACNG8A,KCNJ1A.1,SCN11A,KCNV2,CACNA1SA,KCNJ1A.4,KCNIP3,CX35B,KCNG4A

    Interacting Protein

    CACNA1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1C.

    Resources

    References

    • Wenzel, K; Haase, H; et al. Potential Relevance of alpha(1)-Adrenergic Receptor Autoantibodies in Refractory Hypertension. PLOS ONE 3:-(2008).

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