C4BPB
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Official Full Name
C4b-Binding Protein Beta Chain -
Overview
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. -
Synonyms
C4BP;C4b-binding protein beta chain;complement component 4 binding protein, beta;OTTHUMP00000034288;OTTHUMP00000034289;OTTHUMP00000034374;OTTHUMP00000034375;C4b binding protein, beta chain;complement component 4 binding protein, beta chain;complement component 4-binding protein, beta;C4b-binding protein, beta chain
Recombinant Proteins
- Human
- Human Plasma
- E.coli
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- Non
- His
- GST
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
C4BPB involved in several pathways and played different roles in them. We selected most pathways C4BPB participated on our site, such as Complement and coagulation cascades,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C4BPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | CPB2,PLG,SERPINA1E,SERPINA5,SERPINA1A,VWF,SERPINE1,C3AR1,C4A,C1S |
| Pertussis | IL1A,TRAF6,FOS,CALML5,GNAI1,IL1B,C1QA,SERPING1,MAPK9,CXCL6 |
Protein Function
C4BPB has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C4BPB itself. We selected most functions C4BPB had, and list some proteins which have the same functions with C4BPB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CAMLG,KLC2,DAPK2,ZMYND11,TEKT1,YIF1A,GSK3A,AHSA2,SYT4,ZNF599 |
Interacting Protein
C4BPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C4BPB here. Most of them are supplied by our site. Hope this information will be useful for your research of C4BPB.
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