C4A
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Official Full Name
complement component 4A (Rodgers blood group) -
Overview
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] -
Synonyms
C4A;complement component 4A (Rodgers blood group);C4;RG;C4S;CO4;C4A2;C4A3;C4A4;C4A6;C4AD;CPAMD2;complement C4-A;acidic C4;C4A anaphylatoxin;Rodgers form of C4;acidic complement C4;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- Human Serum
- Human Tissue
- HEK293
- Plasma
- GST
- His
- His&T7
- His&GST
- Non
- His&Fc&Avi
Involved Pathway
C4A involved in several pathways and played different roles in them. We selected most pathways C4A participated on our site, such as Complement and coagulation cascades,Pertussis,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | FCGR4,HIST1H4J,HIST1H2BD,TRIM21,HIST1H2BP,H3F3A,HLA-DQB1,HIST3H2BB-PS,C3,HIST2H3A |
| Staphylococcus aureus infection | FPR1,ITGAM,C5,MASP1,HLA-DQA2,MBL2,CFH,C5AR1,C1QA,PLG |
| Pertussis | CALML5,IRF3,Casp3,IL12A,ITGB1,C5,RHOA,NFKB1,IL23,AMCF-II |
| Complement and coagulation cascades | C1QB,C8G,C9,MBL1,CPB2,SERPING1,C8B,F9,PROC,CR2 |
Protein Function
C4A has several biochemical functions, for example, complement component C1q binding,endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C4A itself. We selected most functions C4A had, and list some proteins which have the same functions with C4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| complement component C1q binding | PTX3,CRP,C1QBP,CALR,APCS,CD93 |
| endopeptidase inhibitor activity | C3,WFDC2,MUG1,SPINT2,RENBP,PROS1,SLPI,MUG2,SPINK1,C3P1 |
Interacting Protein
C4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C4A here. Most of them are supplied by our site. Hope this information will be useful for your research of C4A.
TAF9;APC;p29991-pro_0000037941;clpB;q5nem9_fratt;pelY;holA;adP1;q99ib8-pro_0000045598;d-mannose;MYC;ALB
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References
- Nytrova, P; Potlukova, E; et al. Complement activation in patients with neuromyelitis optica. JOURNAL OF NEUROIMMUNOLOGY 274:185-191(2014).
- Rosner, T; Lohse, S; et al. Epidermal Growth Factor Receptor Targeting IgG3 Triggers Complement-Mediated Lysis of Decay-Accelerating Factor Expressing Tumor Cells through the Alternative Pathway Amplification Loop. JOURNAL OF IMMUNOLOGY 193:1485-1495(2014).
