BRF1
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- Overview
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Official Full Name
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -
Overview
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011] -
Synonyms
BRF1;BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit;BRF;hBRF;BRF-1;GTF3B;TAF3C;TAF3B2;TF3B90;TAFIII90;TFIIIB90;HEL-S-76p;transcription factor IIIB 90 kDa subunit;B - related factor 1;general transcription factor IIIB, 90kD subunit;TBP - associated factor, RNA polymerase III, 90kD;epididymis secretory sperm binding protein Li 76p;TATA box binding protein (TBP)-associated factor 3C;BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB;TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BRF1-336H | Recombinant Human BRF1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| BRF1-180HCL | Recombinant Human BRF1 cell lysate | Human | Non |
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| Brf1-1892M | Recombinant Mouse Brf1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| BRF1-2791H | Recombinant Human BRF1 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| BRF1-3794HF | Recombinant Full Length Human BRF1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 208 amino acids |
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| BRF1-5844H | Recombinant Human BRF1 protein, His-tagged | Yeast | Human | His | 1-677aa |
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Involved Pathway
BRF1 involved in several pathways and played different roles in them. We selected most pathways BRF1 participated on our site, such as Gene Expression,Integrated Pancreatic Cancer Pathway,RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | NR2E3,ZNF563,ZNF354A,ZNF23,ZNF257,HNRNPA0B,ZNF18,ZNF133,RPP40,ZNF100 |
| RNA Polymerase III Transcription Initiation From Type 1 Promoter | GTF3AB,GTF3C3,GTF3C2,GTF3AA,GTF3C4,POLR3GLA,BRF1B,GTF3C5,GTF3A |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | BRF2,SNAPC1,GATAD2AB,NFIC,GTF3C4,POLR3GLA,GTF3AB,SNAPC2,GTF3C2,MBD3A |
| RNA Polymerase III Abortive And Retractive Initiation | NFIA,GTF3C4,NFIB,ZNF143,GTF3C2,SNAPC2,NFIC,SNAPC4,SNAPC5,CRCP |
| RNA Polymerase III Transcription Initiation From Type 2 Promoter | GTF3C3,GTF3C5,GTF3C2,BRF1B,GTF3C4 |
| RNA Polymerase III Transcription | BRF1B,GTF3C5,SNAPC4,SNAPC3,NFIA,GTF3C3,ZFP143,GTF3AA,ZNF143A,NFIB |
| RNA Polymerase III Transcription Initiation | BRF1B,SNAPC1B,GTF3AB,SNAPC1A,GTF3C4,ZNF143,SNAPC1,SNAPC5,ZFP143,ZNF143A |
| Integrated Pancreatic Cancer Pathway | FKBP3,TFF1,TOP2A,TOP1,MYT1,RAPGEF3,MST1,MAPK4,CST3,LEFTY1 |
Protein Function
BRF1 has several biochemical functions, for example, TBP-class protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRF1 itself. We selected most functions BRF1 had, and list some proteins which have the same functions with BRF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TBP-class protein binding | CAND1,DR1,THRA,PSMC6,CAND2,TAF1,HHEX,GTF2A1,PSMC1B,PSMC3 |
| zinc ion binding | TTF2,CA15B,TRIM27,KMT2E,MBD1,Car8,ADAM18,ERAP2,RXRGA,BAZ2A |
Interacting Protein
BRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRF1.
TBP;DTNBP1;ACSL4;Eef1a1;Rab5c;Vbp1;Gpsm1;CCDC132;POLR3E;TCF20
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