BUB1
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Official Full Name
BUB1 mitotic checkpoint serine/threonine kinase -
Overview
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] -
Synonyms
BUB1;BUB1 mitotic checkpoint serine/threonine kinase;BUB1A;BUB1L;hBUB1;mitotic checkpoint serine/threonine-protein kinase BUB1;mitotic spindle checkpoint kinase;putative serine/threonine-protein kinase;budding uninhibited by benzimidazoles 1 homolog;BUB1 budding uninhibited by benzimidazoles 1 homolog
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- Insect (sf21)
- Spodoptera Frugiperda
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BUB1 involved in several pathways and played different roles in them. We selected most pathways BUB1 participated on our site, such as Cell cycle,Oocyte meiosis,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with BUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CUL1,NEK7,NEK9,KAT5,GADD45G,ORC1L,TEX12,NPM1,UBE2V2,GADD45AB |
| Oocyte meiosis | CPEB1,CPEB1A,CUL1,SPDYA,YWHAG1,BTRC,SMC1A,SLKA,ANAPC13,PPP2R5E |
| Progesterone-mediated oocyte maturation | MAP2K1,CDC16,ADCY1B,GNAI1,MAPK9,FZR1A,MAD2L1,PIK3CA,MAPK1,PIK3R3 |
Protein Function
BUB1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by BUB1 itself. We selected most functions BUB1 had, and list some proteins which have the same functions with BUB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
BUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BUB1.
Resources
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References
- Pickhard, A; Grober, S; et al. Survivin and pAkt as potential prognostic markers in squamous cell carcinoma of the head and neck. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 117:733-742(2014).
- Santana, A; Vicente-Salar, N; et al. LIF Insensitivity and Expression of Proteins Activated by DNA Damage Response in Teratoma-Isolated Cells Derived from Mouse Embryonic Stem Cells. CYTOLOGIA 78:195-202(2013).
