BTRC
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Official Full Name
beta-transducin repeat containing E3 ubiquitin protein ligase -
Overview
beta-transducin repeat-containing protein (beta-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F box proteins act as substrate adapters that target protein -
Synonyms
BTRC;beta-transducin repeat containing E3 ubiquitin protein ligase;beta transducin repeat containing;F-box/WD repeat-containing protein 1A;beta TrCP1;betaTrCP;bTrCP;bTrCP1;FBXW1A;Fwd1;beta-TrCP1;E3RSIkappaB;F-box and WD-repeat protein 1B;pIka
Recombinant Proteins
- Mouse
- Cynomolgus
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
BTRC involved in several pathways and played different roles in them. We selected most pathways BTRC participated on our site, such as Oocyte meiosis,Ubiquitin mediated proteolysis,Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian rhythm | CUL1,PRKAG1,CLOCK,PRKAB1,SKP1,FBXL3,ARNTL,PRKAG3,PRKAB2,PER2 |
| Hedgehog signaling pathway | GAS1A,WNT11B,SAP18,CSNK1DA,CSNK1G3,DYRK1A,IHH,PTCH1,PRKACBB,WNT3A |
| Ubiquitin mediated proteolysis | SMURF1,AIRE,TRAF6,UBE2R2,KLHL9,KLHL13,UBE2W,PPIL2,TCEB1B,PRPF19 |
| Shigellosis | ITGA5,NFKBIA,ITGB1,ROCK2,NFKB1,MAPK13,WASF1,WASL,MAPK10,CTTN |
| Wnt signaling pathway | WNT7A,PPARDB,FZD3A,FBXW2,TBL1Y,RAC1,WNT4,FZD7B,DKK4,RAC3 |
| Oocyte meiosis | ANAPC1,CALM2B,ADCY1A,PRKACA,PPP1CA,PPP2R1B,CALM2,PPP1CAA,ANAPC11,INSB |
| Hippo signaling pathway | NF2,FZD7,BIRC5,MOBKL1A,PPP2CB,GLI2,CTNNA2,JUB,FZD8,PARD3 |
Protein Function
BTRC has several biochemical functions, for example, beta-catenin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BTRC itself. We selected most functions BTRC had, and list some proteins which have the same functions with BTRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | UBE2KA,ZNRF2,UBE2L3A,DTX4,ATG3,CDC34A,RNF146,RANBP2,EGR2,MKRN3 |
| contributes_to ubiquitin-protein transferase activity | KLHL4,KEAP1,UBE2S,KLHL30,KLHL17,KLHL38,KLHL26,KLHL5,KLHL40A,KLHDC7B |
| protein binding | VEGFC,GH1,CTDSP1,APBA2,UPF3B,DENR,MRTO4,CLCN1,GTF3C4,TSEN54 |
| beta-catenin binding | SOX17,DACT2,PROP1,APC,RORA,TCF7L1B,PTPRK,PTBP3,EP300,CHD8 |
| protein dimerization activity | NUP210,MITFA,DAO,ERBB2,MAX,CELSR1,HER7,NCOA1,MYCH,NHLH2 |
| ubiquitin protein ligase activity | RNF144AA,SIAH2L,UBE2H,MED23,RBBP6,ANKIB1A,TRAIP,HLTF,RNF222,UHRF1 |
| protein phosphorylated amino acid binding | CRK,ARRB1 |
Interacting Protein
BTRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTRC here. Most of them are supplied by our site. Hope this information will be useful for your research of BTRC.
SKP1;CUL1;CTNNB1
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