BRSK2
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Official Full Name
BR serine/threonine kinase 2 -
Overview
Brain-specific kinase 1 (BRSK1; SAD-B) and Brain-specific kinase 2 (BRSK2; SAD-A) are serine/threonine kinases closely related to AMPK. LKB1 phosphorylates Thr189 in the T-loop of BRSK1 and Thr174 in the T-loop of BRSK2, resulting in activation of the kin -
Synonyms
BRSK2;BR serine/threonine kinase 2;C11orf7, chromsosome 11 open reading frame 7 , STK29;serine/threonine-protein kinase BRSK2;PEN11B;serine/threonine kinase 29;protein kinase SAD1B;brain-selective kinase 2;serine/threonine-protein kinase 29;BR s
Recombinant Proteins
- Human
- Mouse
- Chicken
- Sf9 Insect Cell
- Mammalian Cell
- Sf21 Insect Cell
- Wheat Germ
- Insect Cell
- HEK293
- HEK293T
- E.coli
- In Vitro Cell Free System
- Insect (sf21)
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
BRSK2 involved in several pathways and played different roles in them. We selected most pathways BRSK2 participated on our site, such as Bile acid and bile salt metabolism,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRSK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile acid and bile salt metabolism | SLC27A2,ACOT8,CYP7A1,AKR1C2,NCOA2,SCP2B,SLC27A5,CYP46A1,AKR1C4,AKR1C6 |
| Metabolism | SREBF2,GGTLC1,UGT1B4,MED8,ARSD,PDZD11,PYGMB,B3GNT2A,MOCOS,CYP2C18 |
| Primary bile acid biosynthesis | HSD17B4,CYP46A1.3,CYP46A1,CH25HL1.2,HSD3B7,CYP46A1.1,CH25H,CYP7A1A,AKR1D1,CYP46A1.2 |
| Metabolism of lipids and lipoproteins | GLTPA,CYP24A1,CDS1,AKR1C21,ACOT13,THEM5,EBP,DECR1,CPT2,APOF |
| Synthesis of bile acids and bile salts | SCP2B,SLC27A2A,AKR1C2 |
Protein Function
BRSK2 has several biochemical functions, for example, cholesterol 25-hydroxylase activity,iron ion binding,steroid hydroxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BRSK2 itself. We selected most functions BRSK2 had, and list some proteins which have the same functions with BRSK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cholesterol 25-hydroxylase activity | CH25H |
| iron ion binding | TET1,CYP2J6,CYP2C50,CYP51A1,HBAA,FTH1,FBXL5,CYP2AA2,CYP4V8,CYP4F14 |
| steroid hydroxylase activity | CYP2AD3,FAM84B,CYP2AA9,CYP46A1.4,CYP2C70,CYP2C50,CYP2S1,CYP2X8,CYP2C8,CYP2A4 |
Interacting Protein
BRSK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRSK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRSK2.
KBTBD7;Rrbp1
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