BRMS1
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Official Full Name
breast cancer metastasis suppressor 1 -
Overview
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
BRMS1;breast cancer metastasis suppressor 1;breast cancer metastasis-suppressor 1;DKFZP564A063;AV003220;AW554636;MGC95128;OTTHUMP00000235056;OTTHUMP00000235057;OTTHUMP00000235060;OTTHUMP00000235062
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BRMS1 involved in several pathways and played different roles in them. We selected most pathways BRMS1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDACs deacetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRMS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDACs deacetylate histones | MBD3B,GATAD2AB,SUDS3,MBD3,HMG20B,MBD3A,GATAD2B,MTA2,SAP30L,ARID4A |
| Chromatin modifying enzymes | SMARCA4,ELP3,PBRM1L,SETD3,ING4,KAT8,SMARCA2,PHF20B,MSL1,SMYD3 |
| Chromatin organization | BRD1,PBRM1L,ING3,CHD4A,SMARCD3B,RUVBL2,CHD4,EHMT2,MEAF6,KDM3B |
Protein Function
BRMS1 has several biochemical functions, for example, NF-kappaB binding,contributes_to histone deacetylase activity,histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRMS1 itself. We selected most functions BRMS1 had, and list some proteins which have the same functions with BRMS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TOMM7,PLEKHA2,ZNF580,MATN3,HIST2H4A,MYEF2,PEX3,MAP2K3,HIST1H3C,ZNF232 |
| histone deacetylase binding | BRMS1L,HDAC1,ZMYND15,PKN2,D7ERTD443E,SIX3,SP1,MAGEA2B,PHB,GLI3 |
| NF-kappaB binding | HSPA6,COMMD6,FAF1,DNAJA3,HDAC2,NFKBID,NPM1,PSMA6,ANXA4,NFKBIA |
| contributes_to histone deacetylase activity | SUDS3,SIN3A,SALL1,BRMS1L,BRMS1LA,SIN3B,SIN3AA |
Interacting Protein
BRMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRMS1.
HDAC1;HDAC2;SMARCE1;NMI;CEP70;HDAC4
Resources
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References
- Chimonidou, M; Kallergi, G; et al. BRSM1 Promoter Methylation Provides Prognostic Information in Primary Breast Tumors. MOLECULAR CANCER RESEARCH 11:1248-1257(2013).
- Xiao, LF; Harihar, S; et al. Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopy. ANALYTICA CHIMICA ACTA 843:73-82(2014).
