BRIP1
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Official Full Name
BRCA1 Interacting Protein C-terminal Helicase 1 -
Overview
Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. This protein also appears to be important in ovarian cancer where it seems to act as an antioncogene -
Synonyms
BRIP1;BRCA1 interacting protein C-terminal helicase 1;OF;BACH1;FANCJ;Fanconi anemia group J protein;ATP-dependent RNA helicase BRIP1;BRCA1/BRCA2-associated helicase 1;BRCA1-associated C-terminal helicase 1;BRCA1-binding helicase-like protein;BRCA1-interacting protein C-terminal helicase 1;FLJ90232;MGC126521;MGC126523;BRCA1-interacting protein 1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- HEK293T
- Mammalian Cell
- HEK293
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BRIP1-10291H | Recombinant Human BRIP1, His-tagged | E.coli | Human | His | 1-342a.a. | |
| BRIP1-10HL | Recombinant Human BRIP1 HEK293T cell lysate | HEK293T | Human | Myc&DDK |
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| BRIP1-2494M | Recombinant Mouse BRIP1 Protein | Mammalian Cell | Mouse | His |
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| BRIP1-3260C | Recombinant Chicken BRIP1 | Mammalian Cell | Chicken | His |
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| BRIP1-6136Z | Recombinant Zebrafish BRIP1 | Mammalian Cell | Zebrafish | His |
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| BRIP1-1092M | Recombinant Mouse BRIP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| BRIP1-1092M-B | Recombinant Mouse BRIP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
BRIP1 involved in several pathways and played different roles in them. We selected most pathways BRIP1 participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | REV3L,ATRIP,EME1,EME2,RMI2,RAD51,FANCD2,DCLRE1A,POLK,TELO2 |
Protein Function
BRIP1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,ATP binding,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BRIP1 itself. We selected most functions BRIP1 had, and list some proteins which have the same functions with BRIP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent DNA helicase activity | FBXO18,CHD1,GTF2H4,ERCC3,CHD2,RECQL,BLM,DDX11,DDX3X,CHD4 |
| protein binding | CASK,PEX2,SCGB2A2,MT1X,DHX38,TIA1,IK,GCA,CCDC123,HENMT1 |
| ATP binding | SNRNP200,EPHB2B,TMEM38A,CDK4,ABCE1,RUNX3,NLRC4,MAT2AB,CHD4A,SRPK1A |
| 4 iron, 4 sulfur cluster binding | NFU1,NUBP2,DNA2,ISCU,CDKAL1,ETFDH,REV3L,POLD1,RSAD2,LIAS |
| DNA binding | FOXA,HELZ2,SOX2,UBTFL1,ZNF823,TTF2,HIST1H2AI,PBX3B,THAP8,TCF3 |
| metal ion binding | ZFP536,MUS81,PSMD14,GZF1,PAPOLB,GTSF1L,GALNT4,ZRANB1B,CYP2P10,KCNMA1 |
Interacting Protein
BRIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRIP1.
BRCA1;BLM
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References
- Ren, LP; Xian, YS; et al. Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility. GENETICS AND MOLECULAR RESEARCH 12:5793-5801(2013).
- Dohrn, L; Salles, D; et al. BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1. BIOCHEMICAL JOURNAL 441:919-926(2012).
