BRF1

  • Official Full Name

    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit

  • Overview

    This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

  • Synonyms

    BRF1;BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit;BRF;hBRF;BRF-1;GTF3B;TAF3C;TAF3B2;TF3B90;TAFIII90;TFIIIB90;HEL-S-76p;transcription factor IIIB 90 kDa subunit;B - related factor 1;general transcription factor IIIB, 90kD subunit;TBP - associated factor, RNA polymerase III, 90kD;epididymis secretory sperm binding protein Li 76p;TATA box binding protein (TBP)-associated factor 3C;BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB;TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
Cat.# Product name Source (Host) Species Tag Protein Length Price
BRF1-336H Recombinant Human BRF1 Protein, GST-tagged Wheat Germ Human GST
BRF1-180HCL Recombinant Human BRF1 cell lysate Human Non
Brf1-1892M Recombinant Mouse Brf1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
BRF1-2791H Recombinant Human BRF1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
BRF1-3794HF Recombinant Full Length Human BRF1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 208 amino acids
BRF1-5844H Recombinant Human BRF1 protein, His-tagged Yeast Human His 1-677aa

    Involved Pathway

    BRF1 involved in several pathways and played different roles in them. We selected most pathways BRF1 participated on our site, such as Gene Expression,Integrated Pancreatic Cancer Pathway,RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Pancreatic Cancer Pathway TOP1,RAPGEF3,PPP1R13L,FST,CST3,AGA,TOP2A,NOXA1,JUND,IL11
    RNA Polymerase III Abortive And Retractive Initiation SNAPC5,POU2F1,GTF3C2,BRF2,CRCP,ZNF143,NFIC,GTF3C4,SNAPC1,SNAPC4
    RNA Polymerase III Transcription Initiation From Type 2 Promoter GTF3C3,GTF3C4,BRF1B,GTF3C5,GTF3C2
    RNA Polymerase III Transcription Initiation POLR3GLA,SNAPC1,GTF3AA,SNAPC4,GTF3C3,GTF3C4,POU2F1B,GTF3C2,ZFP143,ZNF143B
    RNA Polymerase III Transcription Initiation From Type 1 Promoter GTF3C2,GTF3C3,GTF3A,GTF3AB,GTF3C4,GTF3AA,POLR3GLA,GTF3C5,BRF1B
    RNA Polymerase III Transcription SNAPC4,NFIC,ZFP143,SNAPC1A,SNAPC1,GTF3C4,NFIB,BRF1B,ZNF143B,GTF3A
    Gene Expression EIF1AX,BARHL1,ZNF747,ZNF350,CLP1,ZNF738,EEF1B2,AIMP2,ZNF202,NR2F1A
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription SNAPC3,CRCP,CBX3,GTF3A,GATAD2B,MTA3,MBD3A,POLR3GLA,ZFP143,NFIB

    Protein Function

    BRF1 has several biochemical functions, for example, TBP-class protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRF1 itself. We selected most functions BRF1 had, and list some proteins which have the same functions with BRF1. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding LDB3A,NUP153,UQCRC2A,ALKBH8,CYHR1,PPARD,TRIM21,LDB3,NR6A1,RNF141
    TBP-class protein binding GTF2A2,TAF1,PSMC5,PSMC1A,TAF1B,BRF1A,PSMC4,DR1,GTF2A1,PSMC2

    Interacting Protein

    BRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRF1.

    TBP;DTNBP1;ACSL4;Eef1a1;Rab5c;Vbp1;Gpsm1;CCDC132;POLR3E;TCF20

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