BRCC3
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Official Full Name
BRCA1/BRCA2-containing complex, subunit 3 -
Overview
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. -
Synonyms
BRCC3;BRCA1/BRCA2-containing complex, subunit 3;chromosome X open reading frame 53 , CXorf53;lys-63-specific deubiquitinase BRCC36;BRCC36;C6.1A;BRISC complex subunit BRCC36;BRCA1-A complex subunit BRCC36;BRCA1/BRCA2-containing complex subunit 36
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&SUMO
- GST
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
BRCC3 involved in several pathways and played different roles in them. We selected most pathways BRCC3 participated on our site, such as Cell Cycle,Cell Cycle Checkpoints,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) | GEN1,RAD1,UIMC1,RAD51AP1,HUS1,TOPBP1,BRE,EME1,RNF168,EME2 |
| DNA Double-Strand Break Repair | RAD9,RAD17,KDM4A,PPP4CB,PARP2,BABAM1,EYA3,WRN,RNF168,RTEL1 |
| G2/M DNA damage checkpoint | FAM175A,BABAM1,BRE,BARD1,THRSP,UIMC1,RNF168,TP53BP1 |
| Cell cycle | SMAD3,YWHABA,NPM1,VRK2,TTK,CCNB3,CDK7,SUN1,CLASP1,CDC7 |
| G2/M Checkpoints | FAM175A,BRE,RAD17,TP53BP1,RAD9A,HUS1,BABAM1,THRSP,RAD9B,RNF168 |
| DNA Repair | FAM175A,RAD51AP1,PPP4CB,COPS5,USP43A,UBE2V2,RNF4,BABAM1,TP53BP1,INO80C |
| DNA Double Strand Break Response | EYA4,KDM4A,BABAM1,SMARCA5,FAM175A,BARD1,UBE2V2,RAD50,BAZ1B,CHEK2 |
| Cell Cycle Checkpoints | CDK5RAP2,HTATIP,RAD50,TP53BP1,HIST4H4,FAM175A,UIMC1,CHEK1,UBE2V2,RAD9 |
Protein Function
BRCC3 has several biochemical functions, for example, enzyme regulator activity,metal ion binding,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCC3 itself. We selected most functions BRCC3 had, and list some proteins which have the same functions with BRCC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme regulator activity | PSMD2,PPP1R7,GCLM,PSMD1,CPN2,MTMR9,PSMD3,SEPT2,APOC3,EIF2B1 |
| protein binding | PRELID1,RPL12,GBP5,IFI35,MPZL3,MED25,CYFIP1,ZNF703,TRIM27,RAB34 |
| ubiquitin-specific protease activity | STAMBP,USP18,COPS5,OTUB1A,USP4,OTUB2,FAM105B,UCHL1,OTUD7A,USP45 |
| polyubiquitin binding | RAD23A,FAM175B,TNIP3,PSMD4A,ZFAND6,AGL,DNAJB2,BRE,HDAC6,DZIP3 |
| metal ion binding | PPM1DB,SETDB1A,ZNF10,ZFP580,NRP2,PHF20B,IMPDH1,KCNIP1B,SMYD4,ENDOG |
| metallopeptidase activity | HE2,NAALAD2,ADAM15,PAPPAA,ADAMTS16,ADAMTS7,MMP23B,TMEM27,AGBL4,ADAM17A |
Interacting Protein
BRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCC3.
BRE;E2F5;NDUFA10;UBC;SHMT2;DDOST;BAG6;ATP5O;MCM2;FAM175B;FAM175A;CAND1;EXOC8;USP7;UIMC1;BABAM1
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