BRAT1
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Official Full Name
BRCA1-associated ATM activator 1 -
Overview
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012] -
Synonyms
BRAT1;BRCA1-associated ATM activator 1;BAAT1;RMFSL;C7orf27;HEAT repeat-containing protein C7orf27;BRCA1-associated protein required for ATM activation protein 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BRAT1-0139H | Recombinant Human BRAT1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| BRAT1-3744Z | Recombinant Zebrafish BRAT1 | Mammalian Cell | Zebrafish | His |
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| BRAT1-255HCL | Recombinant Human BRAT1 cell lysate | Human | Non |
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| BR1-2783H | Recombinant Human BRat 1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Brat1-1813M | Recombinant Mouse Brat1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| BRAT1-2610HF | Recombinant Full Length Human BRAT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 821 amino acids |
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| BRAT1-5239H | Recombinant Human BRAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
BRAT1 involved in several pathways and played different roles in them. We selected most pathways BRAT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BRAT1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAT1 itself. We selected most functions BRAT1 had, and list some proteins which have the same functions with BRAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COG1,MRM1,COX5A,PAN2,KRT7,BEGAIN,BCL9,ISCU,SGTA,FGF21 |
Interacting Protein
BRAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAT1.
BRCA1;ATM;NCBP1;Nipbl;PHF8
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