BPTF
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Official Full Name
bromodomain PHD finger transcription factor -
Overview
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimers disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. -
Synonyms
BPTF;bromodomain PHD finger transcription factor;FALZ, fetal Alzheimer antigen;nucleosome-remodeling factor subunit BPTF;FAC1;NURF301;fetal Alzheimer antigen;fetal Alz-50 clone 1 protein;fetal Alz-50 reactive clone 1;nucleosome remodeling factor
Recombinant Proteins
- Human
- E.coli
- GST
- His&Flag
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BPTF-14H | Recombinant Human BPTF Protein, GST-tagged | E.coli | Human | GST | 2925-3046 a.a. |
|
| BPTF-156H | Recombinant Human BPTF, GST-tagged | E.coli | Human | GST | 2796-2907 a.a. |
|
| BPTF-33H | Recombinant Human BPTF, His&FLAG-tagged | E.coli | Human | His&Flag | 2791-2911 a.a. |
|
| BPTF-80H | Recombinant Human BPTF protein, GST-tagged | E.coli | Human | GST | 2791-2920 |
|
| BPTF-81H | Recombinant Human BPTF protein, His-tagged | E.coli | Human | His | 2791-2920 |
|
| BPTF-82H | Recombinant Human BPTF protein, GST-tagged | E.coli | Human | GST | 2722-2920 |
|
| BPTF-83H | Recombinant Human BPTF protein, His-tagged | E.coli | Human | His | 2722-2920 |
|
| BPTF-1017H | Recombinant Human BPTF Protein (D2865-A3033), Tag Free | E.coli | Human | Non | D2865-A3033 |
|
| BPTF-1018H | Recombinant Human BPTF Protein (D2865-A3033), His tagged | E.coli | Human | His | D2865-A3033 |
|
| BPTF-20H | Recombinant Human BPTF protein(459-657 aa), GST-tagged | E.coli | Human | GST | 459-657 aa |
|
| BPTF-21H | Recombinant Human BPTF protein(361-880 aa), His-tagged | E.coli | Human | His | 361-880 aa |
|
Involved Pathway
BPTF involved in several pathways and played different roles in them. We selected most pathways BPTF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BPTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BPTF has several biochemical functions, for example, contributes_to DNA-dependent ATPase activity,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BPTF itself. We selected most functions BPTF had, and list some proteins which have the same functions with BPTF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NT5C2,KRT25,EIF4EBP3L,NUDT14,ARID1A,PRRC1,ZNF436,FXYD6,TLR1,IKZF1 |
| transcription factor binding | NR0B1,GATA4,TRERF1,MED1,ARRB1,KCNA3,TRP53,PRKDC,DNAJA3,CDK9 |
| sequence-specific DNA binding | HOXC13A,MSXA,ZBTB33,HOXC12,RORB,POU4F2,HOXB4A,POU3F3B,ZKSCAN14,FOXO3 |
| zinc ion binding | UBR2,CTCF,ADAM17A,ESRRGA,QPCTLA,RNF183,LHX1B,TRIM69,ASH1L,MSRB1 |
| contributes_to DNA-dependent ATPase activity | ERCC3,MNAT1,RBBP4,ERCC2,GTF2H2,GTF2H1,GTF2H4,GTF2H3 |
Interacting Protein
BPTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BPTF here. Most of them are supplied by our site. Hope this information will be useful for your research of BPTF.
ms-417;HIST2H4B;H3F3A;SQSTM1;h3_peptide_2-18;hxa9_human_gene;CBX6;MYC
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