BNIP3L
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Official Full Name
BCL2/adenovirus E1B 19kDa interacting protein 3-like -
Overview
Members in the BCL-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. BCL-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including BAD, BAX, BID, BIK, HRK, NIP3, and BIM, form a growing subclass of the BCL-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3, and NIX (for NIP3-like protein X). Bnip3L/Bnip3/Nix is a homolog of the E1B 19K/BCL-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppression by BCL-2 and BCL-XL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins. -
Synonyms
BNIP3L;BCL2/adenovirus E1B 19kDa interacting protein 3-like;BCL2/adenovirus E1B 19kD interacting protein 3 like;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like;BNIP3a;Nix;NIP3L;NIP3-like protein X;adenovirus E1B19k-binding protein B5;BCL2/adenovirus E1B 19-kd protein-interacting protein 3a;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
Recombinant Proteins
- Mouse
- Chicken
- Human
- Cynomolgus
- Rhesus macaque
- Bovine
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Yeast
- E.coli expression system
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
BNIP3L involved in several pathways and played different roles in them. We selected most pathways BNIP3L participated on our site, such as Apoptosis,Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with BNIP3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | FADD,PRKAR1AB,HMGB2,PRKACBB,BOKA,NMT1,DSG1,PPP3R2,IL1A,CASP6L1 |
| Direct p53 effectors | FDXR,AIFM2,CTSD,PLK3,BCL2L14,CSE1L,HIC1,SCN3B,EPHA2,FOXA1 |
Protein Function
BNIP3L has several biochemical functions, for example, identical protein binding,lamin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BNIP3L itself. We selected most functions BNIP3L had, and list some proteins which have the same functions with BNIP3L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lamin binding | TOR1AIP1,IFI27,LBR,SYNE1,PKP1,TMEM201,SUN2,NARF,SUN1,PLCB1 |
| protein heterodimerization activity | UBXN6,PPP3CB,TAF12,HAND1,NR2C2,TFAP2B,ENO2,Itgam&Itgb2,MCL1A,TAF9 |
| protein binding | IL17A,CENPL,IL6ST,RAB43,FBN1,RFC4,SPATC1,PLEKHM1,P2RX4,IFI35 |
| protein homodimerization activity | SPPL3,ABCD1,ALDH1A3,PLDN,PRTFDC1,KIAA0947,CCDC88A,TIMM9,PITX2,CAMK2G |
| identical protein binding | PSME3,SMN2,CEP170L,RGMB,VWA2,PCBD1,DIAP1,CPT1A,MRFAP1L1,CLDN23 |
Interacting Protein
BNIP3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BNIP3L here. Most of them are supplied by our site. Hope this information will be useful for your research of BNIP3L.
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