BEST1
-
Official Full Name
bestrophin 1 -
Overview
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. -
Synonyms
BEST1;bestrophin 1;vitelliform macular dystrophy 2 , VMD2;bestrophin-1;BEST;Best disease;BMD;BEST 1;Best macular dystrophy;BEST1_HUMAN;Bestrophin1;mBest1;TU15B;Vitelliform macular dystrophy 2;Vitelliform macular dystrophy;Vitelliform macular dystrophy protein 2;VMD 2;VMD2;OTTHUMP00000235994;OTTHUMP00000235998;OTTHUMP00000235999;OTTHUMP00000236000;ARB;RP50
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Mus musculus
- Macaca fascicularis
- Sus scrofa (Pig)
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
BEST1 involved in several pathways and played different roles in them. We selected most pathways BEST1 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with BEST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC4A2A,SLC28A3,AQP1A.1,SLC26A3.2,SLC6A19B,SLC6A18,SLC13A4,SLC38A5B,SLC6A11,TTYH3B |
| Stimuli-sensing channels | TRPC4B,CLCNKA,TRPM4C,TRPC4A,ASIC1A,ANO1,Ano3,TRPA1B,CLCN4-2,ANO5B |
| Ion channel transport | CLIC2,CLCN4-2,TRPM1,ANO8,ATP1A1A.2,ATP1A1A.3,ATP6V1G3,BEST4,SLC9B2,SLC17A3 |
Protein Function
BEST1 has several biochemical functions, for example, chloride channel activity,contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BEST1 itself. We selected most functions BEST1 had, and list some proteins which have the same functions with BEST1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to chloride channel activity | BEST3,GABRR2A,BEST4,GABRR3A,GABRQ,GABRZ,BSND,GABRR2,GABRB1,GABRB3 |
| chloride channel activity | CLIC6,CLIC2,FXYD3,FXYD1,SLC26A2,CLCNKB,GABRE,CLIC4,CLCN5,CLCA3 |
Interacting Protein
BEST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BEST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BEST1.
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