BCOR

  • Official Full Name

    BCL6 corepressor

  • Overview

    The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.

  • Synonyms

    BCOR;BCL6 corepressor;BCL6 co repressor;BCL-6 corepressor;FLJ20285;KIAA1575;5830466J11Rik;8430401K06Rik;ANOP 2;ANOP2;BCL 6 co repressor;BCL 6 corepressor;BCL-6 interacting corepressor;FLJ38041;MAA 2;MAA2;MCOPS 2;MCOPS2;MGC131961;MGC71031;BCL6 co-repressor

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
BCOR-10194H Recombinant Human BCOR, GST-tagged E.coli Human GST C-term-360a.a.
BCOR-2974H Recombinant Human BCOR protein, His-tagged E.coli Human His 2-361 aa
BCOR-11661Z Recombinant Zebrafish BCOR Mammalian Cell Zebrafish His
BCOR-174H Recombinant Human BCOR Protein, GST-tagged Wheat Germ Human GST
BCOR-175H Recombinant Human BCOR Protein, GST-tagged Wheat Germ Human GST
BCOR-2361M Recombinant Mouse BCOR Protein Mammalian Cell Mouse His
BCOR-8473HCL Recombinant Human BCOR 293 Cell Lysate HEK293 Human Non
BCOR-0474H Recombinant Human BCOR Protein (Met1569-Trp1755), N-His-tagged E.coli Human His Met1569-Trp1755
BCOR-1004M Recombinant Mouse BCOR Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
BCOR-1004M-B Recombinant Mouse BCOR Protein Pre-coupled Magnetic Beads HEK293 Mouse
BCOR-1557HF Recombinant Full Length Human BCOR Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1004 amino acids
BCOR-556H Recombinant Human BCOR Protein, His-tagged E.coli Human His Leu1501~Trp1755
Bcor-557M Recombinant Mouse Bcor Protein, His-tagged E.coli Mouse His Leu1553~His1755

    Involved Pathway

    BCOR involved in several pathways and played different roles in them. We selected most pathways BCOR participated on our site, such as Signaling events mediated by HDAC Class II, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class II ANKRA2,GATA1

    Protein Function

    BCOR has several biochemical functions, for example, heat shock protein binding,histone deacetylase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCOR itself. We selected most functions BCOR had, and list some proteins which have the same functions with BCOR. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ubiquitin-protein transferase activity CUL3,GAN,UBE2S,KEAP1B,KBTBD6,TCEB3C,KLHL33,KLHL21,KLHL23,KLHL36
    protein binding FCER1G,CEBPA,SNX32,SGOL2,LPXN,RTP2,TBC1D10C,MTSS1,NFATC4,FBXO2
    transcription factor binding STK36,NKX2-1,IGHMBP2,DAXX,FOXA3,SOX10,KDM1A,PARK7,NLK,LMO4
    heat shock protein binding IRAK1,DLST,HSPA6,HSPA1B,PPID,FKBP5,APAF1,GRXCR2,SSUH2.2,DMPK
    transcription regulatory region DNA binding GATA5,GLIS2,CITED1,GATA3,KCNA3,PPARG,SALL2,NKX2-1,SERPINB1A,HNRNPL
    transcription corepressor activity ZNF593,SIAH2,PPP1R13L,KDM5B,SSX3,JUNB,RELB,NAB2,TOB1,TBL1X
    histone deacetylase binding DNMT3B,KLF4,NUDT21,HEY2,DHX36,TFAP4,PKN1,CEBPA,BRMS1,NR2C1

    Interacting Protein

    BCOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCOR here. Most of them are supplied by our site. Hope this information will be useful for your research of BCOR.

    PCGF1;KDM2B;USP7;RING1;RNF2;proS;fabB

    Resources

    Research Area

    Tumor Suppressors

    References

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