BCHE
-
Official Full Name
butyrylcholinesterase -
Overview
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. -
Synonyms
BCHE;butyrylcholinesterase;CHE1, cholinesterase 1;cholinesterase;E1;Acylcholine acylhydrolase;Choline esterase II;Pseudocholinesterase;Butyrylcholine esterase;CHE1;CHLE_HUMAN;cholinesterase 1;OTTHUMP00000212636
Recombinant Proteins
- Human
- Mouse
- Equine
- Chicken
- Dog
- Rat
- HEK293
- E.coli
- CHO-K1
- Mammalian cells
- CHO
- Horse Serum
- Equine Serum
- Trichoplusia Ni Larval
- Wheat Germ
- Mammalian Cell
- Human Cell
- Human Serum
- Yeast
- HEK293T
- His
- Non
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BCHE involved in several pathways and played different roles in them. We selected most pathways BCHE participated on our site, such as Glycerophospholipid biosynthesis,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCHE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of lipids and lipoproteins | ACOT11B,DPEP1,SLC25A1,MED9,SACM1LA,NEU4,ACOT2,APOA4B.2,CYP24A1,CYP2Y3 |
| Glycerophospholipid biosynthesis | PEMT,CPNE1,CPNE7,AGPAT1,PNPLA8,AGPAT2,STIL,SLC44A5B,PLB1,PLD6 |
| Metabolism | MED25,CYP2A7,CKMT2,AKR1C21,SLC25A21,AKAP5,SREBF2,CBLC-1,YY2,TACO1 |
| Metabolism of proteins | TUBA3D,NSMCE2,STT3A,PROCA,CNIH3,CNIH,B3GNT2A,IGFBP6B,MPDU1A,IGFBP5B |
| Neuronal System | NCALDA,KCND2,KCNG3,KCNJ1A.3,PANX2,KCNB2,KCNK2,RERG,KCNQ2,DLG3 |
| Peptide hormone metabolism | CPB2,GRP,CGB7,EXOC8,PCSK1,SLC30A5,SLC30A6,CPE,CPA3,PCSK2 |
Protein Function
BCHE has several biochemical functions, for example, acetylcholinesterase activity,beta-amyloid binding,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCHE itself. We selected most functions BCHE had, and list some proteins which have the same functions with BCHE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | SYN3,AGXTA,OLFM4,PKMB,DIP2B,CTHL,DPYDB,MED16,PPM1LB,PPM1E |
| enzyme binding | CRB2,PRKCE,CCDC99,PDCD2,LAMB1,AKIRIN2,HMOX1,TRIO,LDB2,PHKG1 |
| cholinesterase activity | CELL,CEL.1,CHKA,ACHE |
| acetylcholinesterase activity | ACHE |
| choline binding | CRP,SLC5A7,CHKA |
| identical protein binding | ATL3,BLOC1S6,SETX,CCDC91,BIN1,SYNE1,MTSS1,CCT7,S100A2,DVL1 |
| beta-amyloid binding | LDLRAD3,APBB3,ITM2C,HBA-A2,APOEB,PION,LDLRAP1,APOE,ARMCX5-GPRASP2,Apba1 |
Interacting Protein
BCHE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCHE here. Most of them are supplied by our site. Hope this information will be useful for your research of BCHE.
Sgol2
Resources
Research Area
Neurotransmitter Associated EnzymesPhosphatases and Regulators
Acetylcholine Muscarinic Receptors
Acetylcholine Nicotinic Receptors
Related Services
Related Products
References
- Schopfer, LM; Masson, P; et al. Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome. ANALYTICAL BIOCHEMISTRY 461:17-26(2014).
- Schneider, JD; Marillonnet, S; et al. Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana. PLANT BIOTECHNOLOGY JOURNAL 12:832-839(2014).
