BCAT1
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Official Full Name
branched chain amino-acid transaminase 1, cytosolic -
Overview
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the;reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell;growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination:;hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme,;mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been;described. -
Synonyms
BCAT1;branched chain amino-acid transaminase 1, cytosolic;BCT1, branched chain aminotransferase 1, cytosolic;branched-chain-amino-acid aminotransferase, cytosolic;cytosolic;BCAT;BCAT(c);BCAT1_HUMAN;BCT1;Branched chain amino acid aminotransferase, cytosolic;Branched-chain-amino-acid aminotransferase;DKFZp686E12175;EC 2.6.1.42;ECA39;MECA39;PNAS 121;Protein ECA39;placental protein 18;branched chain aminotransferase 1, cytosolic;PP18;BCATC;PNAS121
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His&T7
- His
- Non
- His&Strep
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
BCAT1 involved in several pathways and played different roles in them. We selected most pathways BCAT1 participated on our site, such as Cysteine and methionine metabolism,Valine, leucine and isoleucine degradation,Valine, leucine and isoleucine biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| -Oxocarboxylic acid metabolism | IDH3A,GPT2,AADAT,IDH3G,GPT,BCAT2,IDH3B,ACY1,GOT1,IDH2 |
| Valine, leucine and isoleucine degradation | MCCC2,HMGCLL1,MUT,ACAA1A,PCCB,AUH,AOX3L1,ALDH2.2,ALDH9A1A.1,HIBADHB |
| Cysteine and methionine metabolism | BHMT,MPST,MTAP,CTH,GOT2,DNMT3,CBS,MDH1AA,IL4I1,CBSB |
| Valine, leucine and isoleucine biosynthesis | BCAT2 |
| Pantothenate and CoA biosynthesis | DPYDB,VNN2,COASY,VNN1,UPB1,ENPP1,DPYD,PANK4,PPCS,BCAT2 |
| Biosynthesis of amino acids | ALDH7A1,PAH,PGAM1A,RPIA,TKT,TPI1,PRPS1B,GOT1,ALDOB,TKTL2 |
| Metabolic pathways | HPSE2,LDHBA,ATP5B,SPHK1,GK,HPDA,ANPEPB,PPAP2D,PAH,G6PC |
Protein Function
BCAT1 has several biochemical functions, for example, L-isoleucine transaminase activity,L-leucine transaminase activity,L-valine transaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAT1 itself. We selected most functions BCAT1 had, and list some proteins which have the same functions with BCAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-leucine transaminase activity | BCAT2 |
| identical protein binding | RASSF1,NCL,CEP170L,EPOR,PVRL2,CHMP4B,GLE1,SERPINA1A,OMG,HNRNPC |
| branched-chain-amino-acid transaminase activity | BCAT2 |
| L-valine transaminase activity | BCAT2 |
| L-isoleucine transaminase activity | BCAT2 |
Interacting Protein
BCAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAT1.
KDM1A;PRMT6;SMAD5
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